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Abstract
Fifty cases of cancer, including stomach, duodenum, and colorectum, have been studied
with HN2 injected intraluminally at operation at a dose of 0.4 mg. per kilogram in
29 patients and 0.8 mg. per kilogram in 21 cases. There was rapid absorption of HN2
in the colorectum cases. In the stomach there was proved absorption in only one of
3 cases. Technical difficulties in drawing blood samples from the efferent veins precluded
data in the other cases. There was no apparent increase in morbidity or mortality
rates in the group which had received 0.4 mg. per kilogram, but there was toxicity
with a marked increase in mortality in the group receiving 0.8 mg. per kilogram of
HN2. Absorption of HN2 is through critical areas at a time when the majority of viable
cancer cells are probably traversing these routes. One case of cancer of the rectosigmoid
has been presented with some experimental background in a new series utilizing 5-FU;
absorption is again rapid. Our technique of adjuvant chemotherapy adds little time
to the standard operative procedure. It is economical, simple, and may be an effective
method for increasing survival rates. It is our hope that it will be tried by other
workers in this field and adapted for newer and more effective drugs as they are developed.
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References
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Article info
Footnotes
☆This work was supported by the Health Research Council of the City of New York under contract No. U-1207. Prior to Jan. 1, 1962, this work was supported by the Given Fund.
☆☆Read at the Twenty-third Annual Meeting of the Society of University Surgeons, Cleveland, Ohio, Feb. 8–10, 1962.
Identification
Copyright
© 1962 Published by Elsevier Inc.
