Society of University Surgeons| Volume 52, ISSUE 1, P259-265, July 1962

Specific pancreatic enzymes in the etiology of acute cholecystitis

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      When measured physiological amounts of trypsin, trypsinogen, or chymotrypsin were injected into the obstructed gallbladder, acute cholecystitis resulted after 48 hours. Obstruction alone, intrinsic bacteria, and pH change did not appear to be significant etiological factors within the same period.
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