Research Article| Volume 51, ISSUE 6, P708-717, June 1962

Thyroid carcinoma in patients with hyperparathyroidism

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      Of 93 patients with parathyroid adenomas studied at the University of California Medical Center, 7, or 7.5 per cent, were found to have associated thyroid carcinoma. This number represents 10.8 per cent of those operated upon by the University's surgical staff. Thyroid adenomas or nodules were found in 49.5 per cent of the thyroid glands. The expected incidence of thyroid carcinoma in this same patient population is 0.0032 per cent. One proposed explanation for our relatively high incidence is the possibility that calcium acts as a goitrogen, and carcinoma occurs after prolonged continuous stimulation.
      Our experience emphasizes the importance of carefully examining the thyroid gland at operation when parathyroid adenomas are removed. The high incidence of associated thyroid carcinoma should be considered carefully by the surgeon when the thyroid gland is exposed and is available for thorough examination.
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