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Abstract
Of 93 patients with parathyroid adenomas studied at the University of California Medical
Center, 7, or 7.5 per cent, were found to have associated thyroid carcinoma. This
number represents 10.8 per cent of those operated upon by the University's surgical
staff. Thyroid adenomas or nodules were found in 49.5 per cent of the thyroid glands.
The expected incidence of thyroid carcinoma in this same patient population is 0.0032
per cent. One proposed explanation for our relatively high incidence is the possibility
that calcium acts as a goitrogen, and carcinoma occurs after prolonged continuous
stimulation.
Our experience emphasizes the importance of carefully examining the thyroid gland
at operation when parathyroid adenomas are removed. The high incidence of associated
thyroid carcinoma should be considered carefully by the surgeon when the thyroid gland
is exposed and is available for thorough examination.
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References
- The occurrence of thyroid carcinoma in San Francisco.New England J. Med. 1955; 253: 45
- Protein manifestations of hyperparathyroidism.North Carolina M. J. 1959; 19: 479
- Thyroid adenoma in experimental animals.Am. J. Cancer. 1935; 23: 550
- Malignant thyroid tumors occurring in the mouse after prolonged hormonal inbalance during the ingestion of thiouracil.J. Clin. Endocrinol. 1951; 11: 1281
- Gross and microscopic findings in clinically normal thyroid glands.J. Clin. Endocrinol. 1955; 151: 1270
- Observations on the incidence of thyroid cancer in the United States.New England J. Med. 1956; 255: 889
- Primary hyperparathyroidism and papillary adenocarcinoma of the thyroid.in: ed. 2. Proc. Staff Meet. Mayo Clin. 31. 1956: 205
- Studies in experimental goitre, VII: Thyroid carcinomata in rats treated with thiourea.Brit. J. Exper. Path. 1946; 27: 294
- Studies on experimental goitre, VIII: Tumors in rats treated with thiourea.Brit. J. Exper. Path. 1947; 28: 46
- Studies in experimental goitre: Malignant change in transplantable rat thyroid tumour.Brit. J. Cancer. 1951; 5: 301
- Tumors of the parathyroid glands found incidentally during surgical procedures.Surg. Gynec. & Obst. 1960; 111: 451
Reynolds, T.: Personal communication.
- Calcium as a goitrogen.J. Clin. Endocrinol. 1954; 14: 1412
Article info
Publication history
Received:
August 15,
1961
Identification
Copyright
© 1962 Published by Elsevier Inc.
