Research Article| Volume 51, ISSUE 6, P738-745, June 1962

The accumulation and removal of excess lactate in arterial blood during hypothermia and biventricular bypass

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      • 1.
        1. Excess lactate content of arterial blood rose during cooling in 6 patients operated upon for correction of various intracardiac lesions. This accumulation of excess lactate reflected an increasing metabolic acidosis secondary to tissue hypoxia.
      • 2.
        2. The hypoxic acidosis of cooling continued until the temperatures of the peripheral muscle mass and the viscera were approximately the same.
      • 3.
        3. During warming, there was a further drop in pH. This acidosis, however, was characterized by a fall in excess lactate and a rise in carbon dioxide tension.
      • 4.
        4. The data, confirming previous findings in dogs, indicate that a metabolic acidosis occurs during cooling which tends to be corrected during warming. A further acidosis, not of hypoxic origin, occurs during warming.
      • 5.
        5. The acidosis associated with cooling and warming may be increased by other complications such as reduced machine output, arrhythmias, and difficult cannulations.
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