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- 1.1. Excess lactate content of arterial blood rose during cooling in 6 patients operated upon for correction of various intracardiac lesions. This accumulation of excess lactate reflected an increasing metabolic acidosis secondary to tissue hypoxia.
- 2.2. The hypoxic acidosis of cooling continued until the temperatures of the peripheral muscle mass and the viscera were approximately the same.
- 3.3. During warming, there was a further drop in pH. This acidosis, however, was characterized by a fall in excess lactate and a rise in carbon dioxide tension.
- 4.4. The data, confirming previous findings in dogs, indicate that a metabolic acidosis occurs during cooling which tends to be corrected during warming. A further acidosis, not of hypoxic origin, occurs during warming.
- 5.5. The acidosis associated with cooling and warming may be increased by other complications such as reduced machine output, arrhythmias, and difficult cannulations.
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Received: October 2, 1961
☆This investigation was supported in part by United States Public Health Grants A 1814 and H 1334.
© 1962 Published by Elsevier Inc.