Research Article| Volume 51, ISSUE 6, P764-766, June 1962

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Gradations of pancreatitis, edematous, through hemorrhagic, experimentally produced by controlled injection of microspheres into blood vessels in dogs

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      • 1.
        1. By the controlled injections of sterile polyethylene microspheres varying in size from 8 to 400 μ, all gradations of pancreatitis could be produced in dogs.
      • 2.
        2. The severity of the lesion was inversely proportional to the size of the microsphere: the larger the microsphere, the less severe the lesion.
      • 3.
        3. Hemorrhagic pancreatitis was produced in 11 hours in every instance with microspheres 8 to 20 μ in size.
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