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Abstract
Local inflammation results in a unique, specific decrease in insoluble collagen from
the uninjured skin of rats distal to the site of wounding. Topical treatment of the
local injury will increase the duration and quantity of this response, presumably
as a consequence of re-establishing the microcirculatory connections between the wound
and the circulation. This loss of dermal collagen is quantitatively duplicated by
application of mild stress to uninjured animals and these results suggest that in
some fashion insoluble collagen is uniquely sensitive to stress.
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References
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Article info
Publication history
Received:
August 14,
1961
Footnotes
☆Supported in part by Grant-in-Aid A-3862 from the National Institute of Arthritis and Metabolic Diseases, United States Public Health Service, Bethesda, Md.
Identification
Copyright
© 1962 Published by Elsevier Inc.
