This paper is only available as a PDF. To read, Please Download here.
Local inflammation results in a unique, specific decrease in insoluble collagen from the uninjured skin of rats distal to the site of wounding. Topical treatment of the local injury will increase the duration and quantity of this response, presumably as a consequence of re-establishing the microcirculatory connections between the wound and the circulation. This loss of dermal collagen is quantitatively duplicated by application of mild stress to uninjured animals and these results suggest that in some fashion insoluble collagen is uniquely sensitive to stress.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- The determination of hexosamine according to Elson and Morgan.Acta Chem. scandinav. 1948; 2: 467
- Chemical and histochemical sequences in the normal healing of wounds.New England J. Med. 1955; 253: 847
- Some systemic chemical responses to local inflammation.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 98. 1958: 655
- Some chemical aspects of inflammation.Am. Surgeon. 1959; 25: 344
- The chemical dissection of rat skin.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 105. 1960: 324
- Distant dermal collagen response to local inflammation.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 106. 1961: 145
- The chemistry of local dermal inflammation.J. Invest. Dermat. 1961; 36: 451
- Dermal chemistry of local necrotic ulceration.Surgery. 1962; 51: 382
- Inhibition of inflammation and the acceleration of tissue repair by cartilage powder.Surgery. 1962; 51: 632
- A chemical description of inflammation and repair.Surg. Gynec. & Obst. 1959; 109: 85
- A modified method for the determination of hydroxyproline.in: ed. 2. Proc. Soc. Exper. Biol. & Med. 83. 1953: 461
Received: August 14, 1961
☆Supported in part by Grant-in-Aid A-3862 from the National Institute of Arthritis and Metabolic Diseases, United States Public Health Service, Bethesda, Md.
© 1962 Published by Elsevier Inc.