Research Article| Volume 51, ISSUE 6, P770-773, June 1962

The effect of local necrosis upon the collagen content of uninjured distal skin

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      Local inflammation results in a unique, specific decrease in insoluble collagen from the uninjured skin of rats distal to the site of wounding. Topical treatment of the local injury will increase the duration and quantity of this response, presumably as a consequence of re-establishing the microcirculatory connections between the wound and the circulation. This loss of dermal collagen is quantitatively duplicated by application of mild stress to uninjured animals and these results suggest that in some fashion insoluble collagen is uniquely sensitive to stress.
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