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Studies relating to the influence of vasopressors and vasodilators upon mean blood pressure and coronary sinus flow are reported. All vasopressors studied increased coronary sinus flow and blood pressure. In normovolemic dogs, Levophed and Aramine increased coronary sinus flow more than Aramine and Neo-synephrine, and Neo-synephrine more than Aramine. Infusions of Levophed brought about far greater increase in flow than infusions of Aramine, in both normovolemic and moderately hypovolemic animals. Both drugs elevated coronary sinus oxygen saturation markedly. Coronary flow in dogs fell substantially after 20 c.c. of blood per kilogram of body weight was withdrawn. Arfonad and Bistran reduced coronary sinus flow in roughly a proportionate degree to the fall in blood pressure induced.
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Received: August 25, 1961
☆Supported in part by Grant H-2035 C5 from the National Heart Institute, National Institutes of Health, Public Health Service, and in part by grants from the James Whitcomb Riley Memorial Association and the Indiana Heart Association.
© 1962 Published by Elsevier Inc.