Research Article| Volume 51, ISSUE 6, P786-792, June 1962

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Control of hemorrhage from the heart and aorta utilizing a plastic adhesive

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      A plastic adhesive methyl 2-cyanoacrylate (Eastman 910 Monomer) which polymerizes on pressure was used as a hemostatic agent in combination with a reinforcing muscle patch. It was found to be effective in the heparinized and nonheparinized animal and to provide a bond which remained secure at systolic blood pressure levels of 300 to 400 mm. Hg. No evidence of toxicity, excessive adhesion formation, or intravascular thrombosis was found when the plastic used was in the amounts required to control bleeding.
      It is felt that this adhesive should be a useful adjuvant as a hemostatic agent in the clinical situation where uncontrolled bleeding from major blood vessels is encountered during surgery.
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