This paper is only available as a PDF. To read, Please Download here.
Abstract
- 1.1. A procedure has been described that employs preferential cerebral hypothermia after induction of circulatory arrest. Extracorporal circulation, pump oxygenator, heat exchangers, and donor blood are not required.
- 2.2. Normothermic animals have tolerated 20 minutes of circulatory arrest without injury and 40 minutes with spinal cord but no cerebral injury. Animals previously cooled to moderately hypothermie levels have survived 60 minutes of arrest without clinical signs of injury. In the latter group, half the animals subjected to 105 minutes of arrest survived, but sustained brain damage.
- 3.3. A procedure for the treatment of emergency cardiac arrest or cardiopulmonary by-pass failure was described.
- 4.4. Factors influencing the experimental results as well as the possibility of clinical applications to elective cardiac and neurosurgery were discussed.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Protective effect of hypothermia on total occlusion of the cerebral circulation.Ann. Surg. 1962; 155: 312
- Suspended animation in cooled, supercooled and frozen rats.J. Physiol. 1955; 128: 547
- Oxygen transport and utilization in dogs at low body temperatures.Am. J. Physiol. 1950; 160: 125
- An effective blood heat exchanger for deep hypothermia in association with extracorporeal circulation but excluding the oxygenator.J. Thoracic & Cardiovas. Surg. 1960; 40: 237
- The protective effect of hypothermia in cerebral ischemia: Experimental and clinical application by selective brain cooling in the human.Surgery. 1962; 52: 15
- Experimental production of cerebral hypothermia by ventricular perfusion techniques.J. Neurosurg. 1963; 20: 112
- The mechanism of death after resuscitation following acute circulatory failure.Surgery. 1955; 38: 696
- anatomic and angiographic study of the vertebral-basilar arterial system in the dog.Am. J. Anat. 1962; 110: 187
- Tha metabolism of normal and tumour tissue. XIII. Neutral salt effects.Biochem. J. 1935; 29: 1468
- Profound hypothermia.Lancet. 1959; 1: 745
- The effect of temperature on the oxygen consumption of cerebral tissue slices.J. Neurophysiol. 1944; 7: 117
- Physiology of cardiac surgery: Hypothermia, extracorporeal circulation and extracorporeal cooling.in: Charles C Thomas, Publisher, Springfield, Ill1959: 96
- Über die Erholung des Gehirns nach Kompletter Ischamie bei Hypothermie.Pflügers Arch. ges. Physiol. 1957; 265: 314
- Localized cerebral hypothermia induced by 0 °C. saline infusion after circulatory arrest.in: ed. 15. Fed. Proc. 22. 1963: 223
- Brain cooling method as an aid to open-heart surgery in special reference to its applications to the repair of atrial septal defects.J. Cardiovas. Surg. 1962; 3: 99
- Anoxia of canine brain without damage.J. A. M. A. 1963; 183: 1085
- Tolerance of adult rats to profound hypothermia and simultaneous cardiac standstill.Surgery. 1954; 36: 25
- Direct extravascular brain cooling in the normothermic animal.Neurology. 1962; 12: 882
- Extravascular local cooling of the brain in man.J. Neurosurg. 1963; 20: 8
- Tolerance of temporary occlusion of the thoracic aorta in the normothermic and hypothermic dogs.Surgery. 1955; 38: 38
- Brain cooling in the prevention of brain damage during periods of circulatory occlusion in dogs.Ann. Surg. 1954; 140: 284
- Partial resolution of the enzymes catalyzing oxidative phosphorylation: I. Purification and properties of soluble DNP-stimulated ATP-ase.J. Biol. Chem. 1960; 235: 3322
- Profound hypothermia combined with extracorporeal circulation for open-heart surgery.Surgery. 1960; 48: 432
- Effects of mannitol and urea on experimental cerebral anoxia.Surgery. 1962; 51: 373
- Resuscitation of hamsters after supercooling or partial crystallization at body temperature below 0 °C.Nature. 1954; 173: 1136
- Temporary arrest of the circulation to the central nervous system.Arch. Neurol. & Psychiat. 1940; 43: 615
- Selective hypothermic perfusion and circulatory arrest.A. M. A. Arch. Surg. 1962; 84: 292
- An isothermic technique for profound hypothermia and its effect on metabolic acidosis.J. Thoracic & Cardiovas. Surg. 1963; 45: 466
- Circulatory arrest of 30–90 minutes utilizing preferential cerebral hypothermia without extracorporeal circulation.The Physiologist. 1963; 6: 298
Article info
Publication history
Received:
March 2,
1964
Footnotes
☆Supported in part by Tricounty Heart Association of Pennsylvania; United States Public Health Service Grant HE-08066-01; U.S. Army Contract DA-49-007-MD 511, and a National Science Foundation Postdoctoral Fellowship.
Identification
Copyright
© 1965 Published by Elsevier Inc.
