Research Article| Volume 57, ISSUE 6, P868-875, June 1965

Tissue tolerance and systemic toxicity of 5-fluorouracil, external radiation, and drug-radiation combination in rabbits

      This paper is only available as a PDF. To read, Please Download here.


      The controversy concerning the true nature of atypical cells circulating in the bloodstream in patients undergoing operations for malignancy and the current status of Thio-TEPA as an adjuvant to radical mastectomy in the cure of breast carcinoma are discussed in the introduction.
      The hypothesis that 5-fluorouracil sensitizes the skin in the radical mastectomy site to subsequent external radiation has been tested in the rabbit and subsequently observed in 17 patients with carcinoma of the breast.
      Both the laboratory and clinical material suggest that the antitumor agent has no effect on the skin when administered prior to external radiation and that there is no apparent contraindication to the use of a combined cancer chemotherapy-radiation program in the treatment of breast carcinoma.
      The clinical results of this combined program are being studied on a long-term basis.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Allarie F.J.
        • Thieme E.T.
        • Korst D.R.
        Cancer chemotherapy with 5-fluorouracil alone and in combination with x-ray therapy.
        Cancer Chem. Rep. 1961; 4: 59
      1. Ansfield, F. J.: Personal communication.

        • Candar A.
        • Ritchie A.C.
        • Hopkirk A.F.
        • Long R.D.
        The prognostic value of circulating tumor cells in patients with breast cancer.
        Surg. Gynec. & Obst. 1962; 115: 291
        • Curreri A.R.
        • Ansfield F.J.
        • McIver F.A.
        • Waisman H.A.
        • Heidelberger C.
        Clinical studies with 5-fluorouracil.
        Cancer Res. 1958; 18: 478
        • Delarue N.C.
        The management of primary breast cancer.
        Surg. Gynec. & Obst. 1964; 118: 133
        • Demaree E.W.
        • Sharp G.S.
        Experience with 5-fluorouracil in metastatic cancer of the breast.
        Cancer Chem. Rep. 1962; 25: 95
        • Engell H.C.
        Cancer cells in the blood; a five to nine year follow-up study.
        Ann. Surg. 1959; 149: 457
        • Fleming J.A.
        Tumour cells in the blood in carcinoma of the breast.
        in: ed. 15. Proc. Roy. Soc. Med. 56. 1963: 497
      2. Floody, R. J.: Personal communication.

        • Halsted W.S.
        The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June, 1889, to January, 1894.
        Ann. Surg. 1894; 20: 497
        • Ivy H.K.
        Treatment of breast cancer with 5-fluorouracil.
        Ann. Int. Med. 1962; 57: 598
      3. Kahn, Reuben L.: Personal communication.

        • Landell N.E.
        • Silvan A.
        • Zajicek J.
        Atypical cells in peripheral blood in 100 cases of mammary carcinoma and 100 controls.
        Acta cytol. 1963; 7: 91
        • Lewison E.F.
        • Smith R.T.
        Results of breast cancer treated at Johns Hopkins Hospital, 1946–1950. Comparison of results and discussion of survival in relation to treatment.
        Surgery. 1963; 53: 644
        • Malmgren R.S.
        • Pruitt J.C.
        • Del Vecchio P.R.
        • Potter J.F.
        A method for the cytological detection of tumor cells in whole blood.
        J. Nat. Cancer Inst. 1958; 20: 1203
        • Moore G.E.
        • Ross C.A.
        • Stiver Jr., R.B.
        Chemotherapy as an adjuvant to surgery.
        Am. J. Surg. 1963; 105: 591
        • Noer R.J.
        • the Surgical Adjuvant Chemotherapy Breast Group
        Effectiveness of Thio-TEPA (Triethylenethiophosphoramide) as adjuvant to radical mastectomy for breast cancer.
        Ann. Surg. 1961; 154: 629
        • Noer R.J.
        Adjuvant chemotherapy, Thio-TEPA with radical mastectomy in the treatment of breast cancer.
        Am. J. Surg. 1963; 106: 405
        • Urban J.A.
        Clinical experience and results of excision of the internal mammary lymph node chain in primary operable breast cancer.
        Cancer. 1959; 12: 14
      4. Vermund, H.: Personal communication.

        • Wathe A.L.
        • Sandberg A.A.
        • Moore G.E.
        The prognostic value of tumor cells in the blood.
        Arch. Surg. 1961; 83: 190