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Abstract
The controversy concerning the true nature of atypical cells circulating in the bloodstream
in patients undergoing operations for malignancy and the current status of Thio-TEPA
as an adjuvant to radical mastectomy in the cure of breast carcinoma are discussed
in the introduction.
The hypothesis that 5-fluorouracil sensitizes the skin in the radical mastectomy site
to subsequent external radiation has been tested in the rabbit and subsequently observed
in 17 patients with carcinoma of the breast.
Both the laboratory and clinical material suggest that the antitumor agent has no
effect on the skin when administered prior to external radiation and that there is
no apparent contraindication to the use of a combined cancer chemotherapy-radiation
program in the treatment of breast carcinoma.
The clinical results of this combined program are being studied on a long-term basis.
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Article info
Publication history
Received in revised form:
May 7,
1964
Received:
February 26,
1964
Footnotes
☆Supported by an Institutional Research Grant to the University of Michigan from The American Cancer Society (IN-4OD); administered through the University of Michigan Cancer Research Institute to St. Joseph Mercy Hospital.
Identification
Copyright
© 1965 Published by Elsevier Inc.
