Research Article| Volume 57, ISSUE 6, P886-893, June 1965

The early surgical treatment of burns. II. Clinical application of intravenous vital dye (Patent Blue V) in the differentiation of partial and full-thickness burns

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      Intravenous injection of Patent Blue V dye in burned patients in the immediate postburn period rapidly produces staining of viable tissues in such a manner that the exact limits of third-degree burn are promptly and accurately identified. The method is applicable to burns of all sizes and types.
      The differential stain is fully developed in the burned skin by 10 minutes after injection and remains distinct for approximately 20 minutes. This period of time allows accurate appraisal of the burn and provides a cornerstone upon which subsequent therapeutic decision may be confidently based.
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