Advertisement
Surgery
Advanced searchSave search
Research Article| Volume 57, ISSUE 1, P139-154, January 1965

The role of pH and CO2 in the distribution of blood flow

DOI:https://doi.org/10.5555/uri:pii:0039606065901959
The role of pH and CO2 in the distribution of blood flow
Previous ArticleThe limitations of heparin therapy after arterial reconstruction
Next ArticleThe significance of turbulence in hemic systems and in the distribution of the atherosclerotic lesion
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      • 1.
        1. To delineate the effect of pCO2 and hydrogen ion concentration on the distribution of blood flow, the cardiac output, carotid, coronary, and renal flows have been measured in the following acid-base variations: respiratory acidosis and alkalosis, compensated (THAM) respiratory acidosis, and metabolic acidosis and alkalosis.
      • 2.
        2. Cardiac output, carotid flow, and coronary flow correlate directly with the carbon dioxide tension in the blood, irrespective of the hydrogen ion concentration.
      • 3.
        3. Renal blood flow varies inversely as the carbon dioxide tension, irrespective of the hydrogen ion concentration.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Bohr V.C.
        • Ralis R.J.
        • Westermeyer R.E.
        Changes in renal function during induced capnea of diffusion respiration.
        Am. J. Physiol. 1958; 194: 143
        • Boniface K.L.
        • Brown J.M.
        Effect of carbon dioxide excess on contractile force of heart in situ.
        Am. J. Physiol. 1953; 172: 752
        • Brickner E.
        • Dowds E.
        • Willits B.
        • Selkurt E.
        Mesenteric blood flow as influenced by progressive hypercapnia.
        Am. J. Physiol. 1956; 184: 275
        • Bronk D.W.
        • Gesell R.
        The regulation of respiration. X. Effects of carbon dioxide, sodium bicarbonate, and sodium carbonate on the carotid and femoral flow of blood.
        Am. J. Physiol. 1927; 82: 170
        • Brooker W.J.
        • Ansell J.S.
        • Brown Jr., E.B.
        Effect of respiratory acidosis on renal blood flow.
        in: S. Forum. 10. 1960: 869
        • Brown Jr., E.B.
        • Miller F.
        Tolerance of the dog heart to carbon dioxide.
        Am. J. Physiol. 1952; 170: 550
        • Burnum J.F.
        • Hickam J.B.
        • McIntosh H.D.
        The effect of hypocapnia on arterial blood pressure.
        Circulation. 1954; 9: 89
        • Cathcart E.P.
        • Clark G.H.
        The mode of action of carbon dioxide on the bloodpressure.
        J. Physiol. 1915; 49: 301
        • Clowes Jr., G.H.A.
        • Alichniewicz A.
        • DelGuercio L.R.M.
        • Gillespie D.
        The relationship of postoperative acidosis to pulmonary and cardiovascular function.
        J. Thoracic & Cardiovas. Surg. 1960; 39: 1
        • Clowes Jr., G.H.A.
        Metabolic responses to injury. Part II: Acid-base balance.
        J. Trauma. 1963; 3: 161
        • Clowes Jr., G.H.A.
        • Sagba G.A.
        • Konitaxis A.
        • Tomin R.
        • Hughes M.
        • Simeone F.A.
        Effects of acidosis on cardiovascular function in surgical patients.
        Ann. Surg. 1961; 154: 524
        • Dale H.H.
        • Evans C.L.
        Effects on the circulation of changes in the carbon-dioxide blood content.
        J. Physiol. 1922; 56: 125
        • Dowds E.G.
        • Brickner E.W.
        • Selkurt E.E.
        Renal response to hypercapnia.
        in: Proc. Soc. Exper. Biol. & Med. 84. 1953: 15
        • Dripps R.D.
        • Comroe Jr., J.H.
        The respiratory and circulatory response of normal man to inhalation of 7.6 and 10.4 percent Co2 with a comparison of the maximal ventilation produced by severe muscular exercise, inhalation of CO2 and maximal voluntary hyperventilation.
        Am. J. Physiol. 1946; 149: 43
        • Duggan J.J.
        • Love V.L.
        • Lyons R.H.
        A study of reflex venomotor reactions in man.
        Circulation. 1953; 7: 869
        • Eckenhoff J.E.
        • Hafkenschiel J.H.
        • Landmesser C.M.
        The coronary circulation in the dog.
        Am. J. Physiol. 1947; 148: 582
        • Epstein R.M.
        • Nahas G.G.
        • Mark L.C.
        Circulatory changes following rapid correction of severe hypercapnic acidosis by 2-amino-2-hydroxy-methyl-1, 3-propanediol.
        Ann. New York Acad. Sc. 1961; 92: 500
        • Feinberg H.
        • Gerola A.
        • Katz L.N.
        Effect of changes in blood CO2 level on coronary flow and myocardial O2 consumption.
        Am. J. Physiol. 1960; 199: 349
        • Fieschi C.
        • Angoli A.
        • Galbo E.
        Effects of carbon dioxide on cerebral hemodynamics in normal subjects and in cerebrovascular disease studied by carotid injection of radioalbumin.
        Circ. Res. 1963; 13: 436
        • Franklin K.J.
        • McGee L.E.
        • Ullmann E.A.
        Effects of severe asphyxia on the kidney and urine flow.
        J. Physiol. 1951; 112: 43
        • Goldstein J.D.
        • Dubois E.L.
        The effect on the circulation in man of rebreathing different concentrations of carbon dioxide.
        Am. J. Physiol. 1927; 81: 650
        • Gomori P.
        • Kovach A.G.B.
        • Takacs L.
        • Foldi M.
        • Szabo G.
        • Nagy Z.
        • Wiltner W.
        The control of renal circulation in hypoxia.
        Acta med. Acad. Scient. Hungary. 1960; 16: 43
        • Goodyear A.V.N.
        • Eckhardt W.F.
        • Ostberg R.H.
        • Goodkind M.J.
        Effects of metabolic acidosis and alkalosis on coronary blood flow and myocardial metabolism in the intact dog.
        Am. J. Physiol. 1961; 280: 628
        • Green H.D.
        • Wegria R.
        Effects of asphyxia, anoxia and myocardial ischemia on the coronary blood flow.
        Am. J. Physiol. 1941; 135: 271
        • Greenfield L.S.
        • Ebert P.A.
        Cardiac denervation effect in hypoxia and hypercapnia.
        Arch. Surg. 1963; 87: 717
        • Gregg D.E.
        • Fisher L.G.
        Blood supply to the heart.
        Handbook of Physiology, Circulation. 1963; 2: 1546
        • Haddy F.J.
        • Scott J.B.
        • Florio M.A.
        • Daugherty Jr., R.M.
        • Huizenga J.N.
        Local vascular effects of hypokalemia, alkalosis, hypercalcemia, and hypomagnesemia.
        Am. J. Physiol. 1963; 204: 202
        • Hardgrove M.
        • Roth G.M.
        • Brown G.E.
        The pressor reaction produced by inhalation of carbon dioxide; studies of patients with normal blood pressure and with hypertension.
        Ann. Int. Med. 1938; 12: 482
        • Hilton R.
        • Eichholtz F.
        The influence of chemical factors on the coronary circulation.
        J. Physiol. 1925; 59: 413
        • Hoff E.C.
        • Kell Jr., J.F.
        • Hastings N.
        • Sholes D.M.
        • Gray E.H.
        Vasomotor, cellular and functional changes produced in kidney by brain stimulation.
        J. Neurophysiol. 1951; 14: 317
        • Kety S.S.
        • Schmidt C.F.
        The effects of active and passive hyperventilation on cerebral blood flow, cerebral oxygen consumption, cardiac output and blood pressure of normal young men.
        J. Clin. Invest. 1946; 25: 107
        • Kety S.S.
        • Schmidt C.F.
        The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption of normal young men.
        J. Clin. Invest. 1948; 27: 484
        • Kopeczky F.A.
        • Rayburn C.J.
        • Whitehead R.W.
        • Draper W.B.
        A study of anemia occurring during apnea under diffusion respiration.
        Am. J. Physiol. 1952; 168: 131
        • Lennox W.G.
        • Gibbs E.L.
        The blood flow in the brain and the leg of man, and the changes induced by alteration of blood gases.
        J. Clin. Invest. 1932; 11: 1155
        • Little W.M.
        • Avera J.W.
        • Hoobler S.W.
        Effects of breathing CO2 on blood pressure and renal circulation in normotensive and hypertensive subjects.
        in: Fed. Proc. 8. 1949: 98
        • McElroy Jr., W.T.
        • Gerdes A.J.
        • Brown Jr., E.B.
        Effects of CO2, bicarbonate and pH on the performance of isolated perfused guinea pig hearts.
        Am. J. Physiol. 1958; 195: 412
        • Monroe R.G.
        • French G.
        • Whitten-Berger J.L.
        Effects of hypocapnia and hypercapnia on myocardial contractility.
        Am. J. Physiol. 1960; 199: 1121
        • Nahas G.G.
        • Cavert H.M.
        Cardiac depressant effect of CO2 and its reversal.
        Am. J. Physiol. 1957; 190: 483
        • Nahas G.G.
        • L'Allemand H.
        Circulation in dogs after respiratory arrest induced by curare.
        J. Appl. Physiol. 1956; 8: 468
        • Patterson Jr., J.L.
        • Heyman A.
        • Battey L.L.
        • Ferguson R.W.
        Threshold of response of the cerebral vessels of man to increase in blood carbon dioxide.
        J. Clin. Invest. 1955; 34: 1857
        • Richardson D.W.
        • Wasserman A.J.
        • Patterson Jr., J.L.
        General and regional circulatory responses to change in blood pH and carbon dioxide tension.
        J. Clin. Invest. 1961; 40: 31
        • Schieve J.F.
        • Wilson W.P.
        The changes in cerebral vascular resistance of man in experimental alkalosis and acidosis.
        J. Clin. Invest. 1953; 32: 33
        • Schmidt C.F.
        The influence of cerebral blood-flow on respiration. I. The respiratory responses to changes in cerebral blood flow.
        Am. J. Physiol. 1928; 84: 202
        • Schmidt C.F.
        • Pierson J.C.
        The intrinsic regulation of the blood vessels of the medulla oblongata.
        Am. J. Physiol. 1934; 108: 241
        • Schneider E.C.
        • Truesdell D.
        The effects on the circulation and respiration of an increase in the carbon dioxide content of the blood in man.
        Am. J. Physiol. 1923; 63: 155
        • Sechzer P.H.
        • Egbert L.D.
        • Linde H.W.
        • Cooper D.Y.
        • Dripps R.D.
        • Price H.L.
        Effect of CO2 inhalation on arterial pressure ECG, and plasma catecholamines, and 17-OH corticosteroids in normal man.
        J. Appl. Physiol. 1960; 15: 454
        • Seevers M.H.
        • Stormont R.T.
        • Hathaway H.R.
        Respiratory alkalosis during anesthesia. I. Effects on circulatory, respiratory, and muscular activity.
        J. Pharmacol. & Exper. Therap. 1940; 68: 365
        • Shires T.
        • Eyer S.W.
        Studies in diffusion respiration.
        J. Aviation Med. 1951; 22: 22
        • Sohler T.P.
        • Lothrop G.N.
        • Forbes H.S.
        The pial circulation of normal, non-anesthetized animals. Part II. The effects of drugs, alcohol and CO2.
        J. Pharmacol. & Exper. Therap. 1941; 71: 331
        • Spencer J.N.
        • Parry T.M.
        • Whitehead R.W.
        • Draper W.B.
        The tolerance of the dog under thiopental sodium anesthesia to high concentration of carbon dioxide.
        J. Pharmacol. & Exper. Therap. 1950; 98: 366
        • Stone J.E.
        • Irwin R.L.
        • Wood C.D.
        • Draper W.B.
        • Whitehead R.W.
        Renal blood flow in dogs during diffusion respiration.
        J. Appl. Physiol. 1959; 14: 405
        • Stone J.E.
        • Wells J.
        • Draper W.B.
        • Whitehead R.W.
        Changes in renal blood flow in dogs during the inhalation of 30 percent CO2.
        Am. J. Physiol. 1958; 194: 115
        • Wiggers C.J.
        A study of the direct effect of hypercapnia on the contraction of the mammalian ventricle.
        Am. J. Physiol. 1929; 90: 230
        • Wolff H.G.
        • Lennox W.G.
        Cerebral circulation. XII. The effect on pial vessels of variations in the oxygen and carbon dioxide content of the blood.
        Arch. Neurol. & Psychiat. 1930; 23: 1097

      Article info

      Footnotes

      ☆Supported by United States Public Health Service Grants HE-07632 and HE-04392.

      ☆☆Presented at the Eighteenth Annual Meeting of the Society for Vascular Surgery, San Francisco, Calif., June 21, 1964.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606065901959

      Copyright

      © 1965 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX