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Forty-one dogs were subjected, in 4 groups, to controlled hypotension of 40 mm. Hg for 2 hours. The groups were variously given room air, 100 percent oxygen, 100 percent oxygen by respirator, and 100 percent oxygen at 3 atmospheres pressure to breathe during the period of hypotension.
Mortality rates were 90 percent in the control, 50 percent in those receiving 100 percent oxygen at one atmosphere, and 27 percent in those receiving 100 percent oxygen at 3 atmospheres.
It is believed that any means available for increasing the arterial oxygen content during hemorrhagic hypotension exerts a beneficial effect on mortality rates.
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Received: January 29, 1964
☆This work was supported in part by United States Public Health Service grant HE 02710 and American Heart Association grant 61 G 8.
© 1965 Published by Elsevier Inc.