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Presently available operative procedures on the aortic valve require a prolonged period of direct exposure of the valve. In order to determine the optimal method of myocardial support during such operations, an experimental animal study was done in which anoxic arrest, selective cardiac hypothermia, intermittent coronary perfusion, and continuous coronary perfusion were compared during a one-hour period of aortic occlusion and total cardiopulmonary bypass. Changes in left ventricular contractile force (LVCF) were measured and alterations in electrical activity and glycogen metabolism of the heart were observed. The results of this study suggest that continuous perfusion of the coronary arteries affords the greatest degree of myocardial protection for aortic valve surgery.
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Received in revised form: March 28, 1964
Received: December 5, 1963
☆Supported in part by U. S. Public Health Service Grants HTS-5387 and HE-03137, and the Houston Heart Association.
© 1965 Published by Elsevier Inc.