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Research Article| Volume 57, ISSUE 3, P423-434, March 1965

Indicator-dilution curves obtained across the systemic circulation during cardiopulmonary bypass perfusion

  • Stanley Giannelli Jr.
    Affiliations
    From the Section of Cardiac Surgery and the Cardiopulmonary Laboratory, The St. Vincent's Hospital of the City of New York, New York, N. Y., USA

    From the Departments of Surgery and Medicine, New York University College of Medicine New York, N. Y., USA
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  • Stephen M. Ayres
    Affiliations
    From the Section of Cardiac Surgery and the Cardiopulmonary Laboratory, The St. Vincent's Hospital of the City of New York, New York, N. Y., USA

    From the Departments of Surgery and Medicine, New York University College of Medicine New York, N. Y., USA
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  • James W. Vastola
    Affiliations
    From the Section of Cardiac Surgery and the Cardiopulmonary Laboratory, The St. Vincent's Hospital of the City of New York, New York, N. Y., USA

    From the Departments of Surgery and Medicine, New York University College of Medicine New York, N. Y., USA
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  • Robert A. Goldstone
    Affiliations
    From the Section of Cardiac Surgery and the Cardiopulmonary Laboratory, The St. Vincent's Hospital of the City of New York, New York, N. Y., USA

    From the Departments of Surgery and Medicine, New York University College of Medicine New York, N. Y., USA
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  • Meta E. Buehler
    Affiliations
    From the Section of Cardiac Surgery and the Cardiopulmonary Laboratory, The St. Vincent's Hospital of the City of New York, New York, N. Y., USA

    From the Departments of Surgery and Medicine, New York University College of Medicine New York, N. Y., USA
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DOI:https://doi.org/10.5555/uri:pii:003960606590214X
Indicator-dilution curves obtained across the systemic circulation during cardiopulmonary bypass perfusion
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      Abstract

      Indocyanine-green dye curves were obtained across the systemic circulation in dogs during extracorporal circulation. The curves were easily extrapolated to eliminate the first recirculation.
      The flow rate calculated from the perfusion pump—calibration curve was within 10 percent of the flow rate calculated from the dye curves in 11 of 17 instances. The major cause of this discrepancy is variation in densitometer response to the same increment of dye concentration secondary to hematocrit variations occurring during the course of a perfusion. Further confirmation of indicator-dilution theory in this preparation was demonstrated by the fact that curves withdrawn from different systemic venous sites at constant flow rate, although of different contour, were of essentially the same area.
      When withdrawal was from the main venous return line, systemic vascular volume could be calculated from the product of flow rate, directly read from the pump calibration curve, and from the mean arrival time of the dye. It is not necessary to inject a calibrated quantity of dye.
      Vascular volume did not increase during perfusion, even though there was transfer of large amounts of blood from the extracorporal circuit to the animals because of an anaphylactic-like reaction to homologous plasma. This transfer of blood must be primarily related to expansion of the extravascular compartments, presumably a result of increased capillary permeability.
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      References

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      Article info

      Publication history

      Received: February 3, 1964

      Footnotes

      ☆This study was supported by National Institutes of Health Grant HE-08074-01, and New York City Health Research Council Grant U-1431.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:003960606590214X

      Copyright

      © 1965 Published by Elsevier Inc.

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