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Peptic ulcer in childhood is increasing in incidence and demonstrating an unsuspected virulence. Surgery may thus play an increasing role in the therapy of this disease. An experimental study of the effects of the major operations for peptic ulcer on the growth and nutrition of puppies was carried out. Vagotomy and pyloroplasty did not alter the development of the animals as compared with the control group. Following vagotomy and antrectomy or subtotal gastrectomy there was an immediate loss of weight with a subsequent growth lag and deficit for the entire period of observation. Hematologic, roentgenologic, and fat-absorption studies were normal in all groups. On the basis of this study the authors feel that vagotomy and pyloroplasty will least disturb growth and nutrition in the young, and if this procedure is effective in controlling the ulcer diathesis, it should be the operation of choice in children.
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Received: March 31, 1964
© 1965 Published by Elsevier Inc.