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Research Article| Volume 57, ISSUE 2, P259-268, February 1965

Successful in vitro preservation of the small bowel, including maintenance of mucosal integrity with chlorpromazine, hypothermia, and hyperbaric oxygenation

DOI:https://doi.org/10.5555/uri:pii:0039606065902321
Successful in vitro preservation of the small bowel, including maintenance of mucosal integrity with chlorpromazine, hypothermia, and hyperbaric oxygenation
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      Abstract

      • 1.
        1. Bowel preserved 24 hours in a cold solution develop hemorrhagic necrosis upon revascularization.
      • 2.
        2. Addition of CPZ to the perfusate and storage solution allows successful preservation at 2 to 4 °C. for 24 and 48 hours. Damage occurring with the longer period of preservation is reversible.
      • 3.
        3. Increasing the OHP from 3 to 7.9 atmospheres absolute of oxygen also resulted in successful preservation of the bowel.
      • 4.
        4. The combination of CPZ, OHP, and HPT resulted in improved preservation in terms of length of preservation, amount of initial damage, and rapidity of re-establishment of normal mucosa.
      • 5.
        5. The protective action of CPZ, as has been apparent in the treatment of different kinds of shock, might also be related to a protective action on the cellular level, as shown in the bowel storage experiments.
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      Article info

      Publication history

      Received: September 11, 1964

      Footnotes

      ☆Supported in part by United States Public Health Service Grant A-3361.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606065902321

      Copyright

      © 1965 Published by Elsevier Inc.

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