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- 1.1. Bowel preserved 24 hours in a cold solution develop hemorrhagic necrosis upon revascularization.
- 2.2. Addition of CPZ to the perfusate and storage solution allows successful preservation at 2 to 4 °C. for 24 and 48 hours. Damage occurring with the longer period of preservation is reversible.
- 3.3. Increasing the OHP from 3 to 7.9 atmospheres absolute of oxygen also resulted in successful preservation of the bowel.
- 4.4. The combination of CPZ, OHP, and HPT resulted in improved preservation in terms of length of preservation, amount of initial damage, and rapidity of re-establishment of normal mucosa.
- 5.5. The protective action of CPZ, as has been apparent in the treatment of different kinds of shock, might also be related to a protective action on the cellular level, as shown in the bowel storage experiments.
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Received: September 11, 1964
☆Supported in part by United States Public Health Service Grant A-3361.
© 1965 Published by Elsevier Inc.