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Research Article| Volume 57, ISSUE 2, P280-284, February 1965

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Effects of fibrinolytic enzymes on experimentally induced peritoneal adhesions

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      Abstract

      A new method was developed to provide reproducible experimental peritoneal adhesions in dogs.
      Using 3 different methods to produce experimental adhesions, 3 species of animals (rats, rabbits, dogs), 7 different fibrinolytic enzyme preparations, 2 routes of administration (intraperitoneal and intravenous), and several dose schedules, we were unable to demonstrate significant prophylactic or therapeutic activity.
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