Research Article| Volume 57, ISSUE 2, P335-342, February 1965

Histologic changes in long-term autologous arterial patch grafts in coronary arteries

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      Histologic examination was performed upon 8 autologous arterial patch grafts inserted into the circumflex coronary artery for 3 to 18 months. All arteries remained patent for 6 months, though 2 of the 8 occluded between 6 and 15 months. The histologic sections showed moderate fibrosis replacing 40 to 50 percent of the arterial wall, but the integrity of the arterial wall was well preserved. Smooth muscle cells were present in the media with a frequency estimated at 30 percent of normal.
      Venous patch grafts have been reported to undergo extensive fibrosis within 60 days after insertion, being converted to principally fibrous tissue. Since experimental data indicates that details of technique greatly influence the patency rate following reconstruction of 3 to 4 mm. arteries, it would seem preferable to employ an autologous arterial patch graft for reconstruction whenever patch grafting is used in such small arteries.
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