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Abstract
A primate model for inducing and continuously measuring various biliary tract pressures
while maintaining a controlled interruption of the EHG has been described. Bile flow,
bile salt secretion, and bile salt synthesis have been studied at control, moderately
elevated, and high biliary tract pressures. At high biliary pressures, bile flow and
the bile salt secretion rate were consistently reduced and bile salt synthesis was
completely inhibited. It is proposed that the reduced secretion of bile salts results
in the accumulation of bile salts in the liver with resultant feedback inhibition
of synthesis.
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References
- The physiochemical basis of gallstone formation in man.J. Clin. Invest. 1968; 47: 1043
- Rat biliary tree during short periods of obstruction of the common duct.Amer. J. Physiol. 1963; 205: 1127
- Instrument for measuring and sampling bile flow.Med. Biol. Engin. 1970; 8: 19
- On the regulation of bile acid formation in the rat liver.Acta Physiol. Scand. 1958; 42: 1
- Mechanics of bile secretion: the effects of perfusion pressure and temperature on bile flow and bile secretion pressure.Amer. J. Physiol. 1954; 177: 103
- Bile acids in the serum of jaundiced patients.Gastroenterology. 1961; 41: 285
- Experimental model for the study of the enterohepatic circulation of bile in rhesus monkeys.J. Lab. Clin. Med. 1968; 72: 169
- Effects of controlled interruption of the enterohepatic circulation of bile salts by biliary diversion and ileal resection on bile salt secretion, synthesis, and pool size in the rhesus monkey.J. Clin. Invest. 1970; 49: 232
- Urinary excretion of bile acids in patients with obstructive jaundice and hepatocellular disease.Amer. J. Clin. Path. 1968; 49: 404
- Über den Ruckflüss der Galle bei erhöhtem hydrostatischen Druck im Gallengangsystem der Ratte.Klin. Wschr. 1964; 42: 118
- Liver cell secretion under normal and pathologic conditions studied by fluorescence microscopy on living rats.Acta Physiol. Scand. 1952; 28: 1
- The pressure of bile secretion and the mechanism of bile absorption in obstruction of the bile duct.in: Proc. Roy. Soc. (London) Ser. B79. 1907: 517
- Experimental production of gallstones by incomplete stricture of the terminal common bile duct.Surgery. 1957; 42: 623
- Bile and dry matter output at elevated liver secretion pressure.Acta Chir. Scand. 1964; 128: 153
- The turnover of cholic acid in man.Acta Physiol. Scand. 1957; 40: 1
- The effect of dietary fat on the turnover of cholic acid and on the composition of the biliary bile acids in man.J. Clin. Invest. 1965; 44: 1754
- On the expulsion of bile by the gall bladder; and a reciprocal relationship with sphincter activity.J. Exp. Med. 1926; 44: 173
- Some effects of stenosis of the terminal common bile duct on the biliary tract and liver.N. Eng. J. Med. 1959; 260: 315
- The relationship between taurocholate secretion rate and bile production in the unanesthetized dog during cholinergic blockade and during secretin administration.J. Clin. Invest. 1962; 41: 1152
- The secretion of bile against pressure.Gastroenterology. 1961; 40: 705
- Bile acid content of human serum.J. Clin. Invest. 1957; 36: 530
- Measurement of human serum bile acids by gas liquid chromatography.J. Lipid Res. 1965; 6: 182
- Feedback regulation of bile acid synthesis in the rats.J. Lipid Res. 1969; 10: 646
- Source of abnormal bile in patients with cholesterol gallstones.N. Eng. J. Med. 1970; 283: 53
- The formation of gallstones.Advances Intern. Med. 1970; 16: 243
- The effects of alteration of biliary tract pressure on bile composition—a method for study.Gastroenterology. Sept., 1971; (In press)
- Diminished bile acid pool size in patients with gallstones.Gastroenterology. 1970; 59: 165
- Gallenfluss und maximaler Gallendruck nach kürzerem und längerem Verschluss des Ductus hepaticus bei der Ratte.Klin. Wschr. 1963; 41: 825
Article info
Footnotes
☆Supported by National Institutes of Health Grants No. AMO8726 and No. AM11453 and National Institutes of Health Training Grant No. 1-TO1-GM-01498.
☆☆Presented at the Thirty-second Annual Meeting of the Society of University Surgeons, New Haven, Conn., Feb. 11 to 13, 1971.
Identification
Copyright
© 1971 Published by Elsevier Inc.
