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Original communication| Volume 69, ISSUE 2, P166-174, February 1971

The central lymphoid tissues of rabbits. I. Functional studies in newborn animals

DOI:https://doi.org/10.5555/uri:pii:0039606071901449
The central lymphoid tissues of rabbits. I. Functional studies in newborn animals
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      Abstract

      The absence of the thymus was associated with prolongation of skin allograft survival and impairment of delayed sensitivity in rabbits operated upon and x-irradiated at birth. Antibody production to bacterial antigens was unimpaired in these animals. This observation provides a firm basis for the concept of a distinct thymus-dependent division of the immunologic system of the rabbit, responsible primarily for the execution of cellular immune responses.
      The absence of the appendix was associated with impairment of antibody production to Brucella and Salmonella organisms, without alteration of allograft rejection. This observation supports the concept of a functional equvalent of the avian bursa of Fabricius in the gut-associated lymphoid tissues of the rabbit, responsible primarily for the execution of humoral immune responses.
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      Article info

      Publication history

      Accepted: February 13, 1970

      Footnotes

      ☆Aided by grants from The National Foundation-March of Dimes, the United States Public Health Service (AI-08677, NB-02042), the Minnesota Chapter of the Arthritis Foundation, and the American Heart Association.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606071901449

      Copyright

      © 1971 Published by Elsevier Inc.

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