Original communication| Volume 69, ISSUE 2, P166-174, February 1971

The central lymphoid tissues of rabbits. I. Functional studies in newborn animals

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      The absence of the thymus was associated with prolongation of skin allograft survival and impairment of delayed sensitivity in rabbits operated upon and x-irradiated at birth. Antibody production to bacterial antigens was unimpaired in these animals. This observation provides a firm basis for the concept of a distinct thymus-dependent division of the immunologic system of the rabbit, responsible primarily for the execution of cellular immune responses.
      The absence of the appendix was associated with impairment of antibody production to Brucella and Salmonella organisms, without alteration of allograft rejection. This observation supports the concept of a functional equvalent of the avian bursa of Fabricius in the gut-associated lymphoid tissues of the rabbit, responsible primarily for the execution of humoral immune responses.
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        • Archer O.K.
        • Pierce J.C.
        Role of thymus in development of the immune response.
        in: ed. 3. Fed. Proc. 20. 1961: 26
        • Archer O.K.
        • Sutherland D.E.R.
        • Good R.A.
        Appendix of the rabbit: A homologue of the bursa in the chicken?.
        Nature. 1963; 200: 337
        • Arnason B.G.
        • Jankovic B.D.
        • Waksman B.H.
        • Wennersten C.
        Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth on reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte.
        J. Exp. Med. 1962; 116: 177
        • Cooper M.D.
        • Peterson R.D.A.
        • South M.A.
        • Good R.A.
        The functions of the thymus system and the bursa system in the chicken.
        J. Exp. Med. 1966; 123: 75
        • Cooper M.D.
        • Perey D.Y.
        • Gabrielsen A.E.
        • Sutherland D.E.R.
        • McKneally M.F.
        • Good R.A.
        Production of an antibody deficiency syndrome in rabbits by neonatal removal of organized intestinal lymphoid tissues.
        Int. Arch. Allerg. 1968; 33: 6
        • DiGeorge A.M.
        Congenital absence of thymus and its immunological consequences: Concurrence with congenital hypoparathyroidism.
        in: Immunologic deficiency diseases in man. ed. 3. Birth Defects (Original Articles Series). vol. 4. National Foundation, March of Dimes, New York1968: 116
        • Fichtelius K.E.
        • Laurell G.
        • Philipsson L.
        The influence of thymectomy on antibody formation.
        Acta Path. Microbiol. Scand. 1961; 51: 81
        • Ford C.E.
        • Micklem H.S.
        • Evans E.P.
        • Gray J.G.
        • Ogden D.A.
        The inflow of bone marrow cells to the thymus: Studies with part-body irradiated mice injected with chromosome marked bone marrow and subjected to antigenic stimulation.
        Ann. N. Y. Acad. Sci. 1966; 129: 283
        • Glick B.
        • Chang T.S.
        • Jaap R.G.
        The bursa of Fabricius and antibody production.
        Poult. Sci. 1956; 35: 224
        • Good R.A.
        Agammaglobulinemia—a provocative experiment of nature.
        Bull. Univ. Minn. Hosp. & Minn. Med. Found. 1954; 26: 1
        • Good R.A.
        • Dalmasso A.P.
        • Martinez C.
        • Archer O.K.
        • Pierce J.C.
        • Papermaster B.W.
        The role of the thymus in development of immunologic capacity in rabbits and mice.
        J. Exp. Med. 1962; 116: 773
        • Jankovic B.D.
        • Waksman B.H.
        • Arnason B.G.
        Role of the thymus in immune reactions in rats. I. The immunologic response to bovine serum albumin (antibody formation, Arthus reaction, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth.
        J. Exp. Med. 1962; 116: 159
        • Konda S.
        • Harris T.N.
        Effect of appendectomy and of thymectomy, with x-irradiation, on the production of antibodies to two protein antigens in young rabbits.
        J. Immunol. 1966; 97: 805
        • MacLean L.D.
        • Zak S.J.
        • Varco R.L.
        • Good R.A.
        Thymic tumor and acquired agammaglobulinemia: A clinical and experimental study of the immune response.
        Surgery. 1956; 40: 1010
      1. McKneally, M. F., Sutherland, D. E. R., and Good, R. A.: The central lymphoid tissues of rabbits. II. Functional and morphologic studies in adult animals, Surgery. In press.

        • Miller J.F.A.P.
        The immunological function of the thymus.
        Lancet. 1961; 2: 748
        • Miller J.F.A.P.
        • Doak S.M.A.
        • Cross A.M.
        Role of the thymus in recovery of the immune mechanism in the irradiated adult mouse.
        in: ed. 3. Proc. Soc. Exp. Biol. Med. 112. 1963: 785
        • Nezelof C.
        • Jammet M.L.
        • Lertholary P.
        • Labrune B.
        • Lamy M.
        L'hypoplasie héréditaire du thymus: Sa place et sa responsabilité dans une observation d'aplasie lymphocytaire, normoplasmocytaire, et normoglobulinémique du nourrisson.
        Arch. Franç. Pediat. 1964; 21: 897
        • Nossal G.J.V.
        Studies on the rate of seeding of lymphocytes from the intact guinea pig thymus.
        Ann. N. Y. Acad. Sci. 1964; 120: 171
        • Osoba D.
        • Miller J.F.A.P.
        The lymphoid tissues and immune responses of neonatally thymectomized mice bearing thymus tissue in Millipore diffusion chambers.
        J. Exp. Med. 1964; 119: 177
        • Perey D.Y.
        • Cooper M.D.
        • Good R.A.
        The mammalian homologue of the avian bursa of Fabricius.
        Surgery. 1968; 64: 614
        • Peterson R.D.A.
        • Cooper M.D.
        • Good R.A.
        The pathogenesis of immunologic deficiency diseases.
        Amer. J. Med. 1965; 38: 579
        • Sutherland D.E.R.
        • Archer O.K.
        • Good R.A.
        Role of the appendix in development of immunologic capacity.
        in: ed. 3. Proc. Soc. Exp. Biol. Med. 115. 1964: 673
        • Warner N.S.
        • Szenberg A.
        • Burnet F.M.
        The immunological role of different lymphoid organs in the chicken. I. Dissociation of immunological responsiveness.
        Aust. J. Exp. Biol. Med. Sci. 1962; 40: 373
        • Warwick W.J.
        A rapid sutureless method for grafting skin in rabbits.
        Transplant. Bull. 1962; 30: 51
        • Yunis E.J.
        • Hilgard H.
        • Sjodin K.
        • Martinez C.
        • Good R.A.
        Immunological reconstitution of thymectomized mice by injections of isolated thymocytes.
        Nature. 1964; 201: 784