Advertisement
Original communication| Volume 69, ISSUE 2, P276-283, February 1971

Early plasma protein recovery after total volume plasmapheresis in baboons

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Thirteen baboons were subjected to hypothermic and asanguineous total body perfusion and to replacement with packed, human, red blood cells. In effect, this was a rapid plasmapheresis of approximately 90 percent of the blood volume. Plasma protein refill progressed rapidly with replacement of up to 49 percent in one hour. The protein flow via the thoracic duct was inadequate to account for this rapid refill.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Adamson J.
        • Hillman R.S.
        Blood volume and plasma protein replacement following acute blood loss in normal man.
        J. A. M. A. 1968; 205: 609
        • Birke G.
        • Liljedahl S.O.
        • Plantin L.O.
        • Rieger A.
        Blood volume and plasma protein. I. Changes in blood volume and plasma proteins after bleeding in the splenectomized dog.
        Acta Chir. Scand. 1966; 132: 477
        • Bosman S.C.W.
        • Saunders S.J.
        • Terblanche J.
        • Harrison G.G.
        • Barnard C.N.
        Cross-circulation between man and baboon.
        Lancet. 1968; 2: 583
        • Cope O.
        • Litwin S.B.
        Contribution of the lymphatic system to the replenishment of the plasma volume following a hemorrhage.
        Ann. Surg. 1962; 156: 655
        • Hopkins R.W.
        • Penn I.
        • Simeone F.A.
        Studies of thoracic duct lymph and blood plasma in oligemic hypotension.
        J. A. M. A. 1964; 187: 122
        • Hume D.M.
        • Gayle W.E.
        • Williams G.M.
        Cross-circulation of patients in hepatic coma with baboon partners having human blood.
        Surg. Gynec. Obstet. 1969; 128: 495
        • Klebanoff G.
        • Phillips J.
        Temporary suspension of animation using total body perfusion and hypothermia: A preliminary report.
        Cryobiology. 1969; 6: 121
        • Liljedahl S.O.
        • Rieger A.
        IV. Importance of thoracic-duct lymph in restitution of plasma volume and plasma proteins after bleeding and immediate substitution in the splenectomized dog.
        Acta Chir. Scand. (Suppl.). 1968; 379: 39
        • Lister J.
        • McNeill I.F.
        • Marshall V.C.
        • Plzak L.F.
        • Dagher F.J.
        • Moore F.D.
        Transcapillary refilling after hemorrhage in normal man: Basal rates and volumes; effect of norepinephrine.
        Ann. Surg. 1963; 158: 698
        • Malt R.A.
        • Wang C.
        • Yamazaki Z.
        • Miyakuni T.
        Stimulation of albumin synthesis by hemorrhage.
        Surgery. 1969; 66: 65
        • Moore F.D.
        • Dahger F.J.
        • Boyden C.M.
        • Lee C.J.
        • Lyons J.H.
        Hemorrhage in normal man. I. Distribution and dispersal of saline infusions following acute blood loss: Clinical kinetics of blood volume support.
        Ann. Surg. 1966; 163: 485
        • Neely W.A.
        • Turner M.D.
        • Haining J.L.
        Survival after asanguineous total body perfusion.
        Surgery. 1963; 54: 244
        • Patterson R.M.
        • Ballard C.L.
        • Wasserman K.
        • Mayerson H.S.
        Lymphatic permeability to albumin.
        Amer. J. Physiol. 1958; 194: 120
        • Richmond J.E.
        • Shoemaker W.C.
        • Elwyn D.H.
        Rates of biosynthesis of plasma and liver proteins.
        Amer. J. Physiol. 1963; 205: 848
        • Rodionov V.M.
        • Uspenskaya V.D.
        • Zamyatkina O.G.
        • Grunt T.P.
        • Polyakova V.P.
        Chem. Abstr. 1959; 53: 5461
        • Skillman J.J.
        • Awwad H.K.
        • Moore F.D.
        Plasma protein kinetics of the early transcapillary refill after hemorrhage in man.
        Surg. Gynec. Obstet. 1967; 125: 983
        • Swann H.G.
        • Stegall H.F.
        • Collings W.D.
        • Miles N.A.
        Red cell and albumin circulations in the ileum.
        Amer. J. Physiol. 1961; 201: 943
        • Wasserman K.
        • Mayerson H.S.
        Plasma, lymph and urine studies after dextran infusions.
        Amer. J. Physiol. 1952; 171: 218
        • Wasserman K.
        • Joseph J.D.
        • Mayerson H.S.
        Kinetics of vascular and extravascular protein exchange in unbled and bled dogs.
        Amer. J. Physiol. 1956; 184: 175
        • Yuile C.L.
        • Lucas F.V.
        • Neubecker R.D.
        • Cochrane C.G.
        • Whipple G.H.
        Depletion of reserve protein from extravascular, extracellular fluid.
        J. Exp. Med. 1959; 109: 165