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Ornithine decarboxylase: A defect in liver regeneration following portacaval shunt

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      Abstract

      Following partial hepatectomy in end-to-side portacaval shunted rats ODC in residual liver is not activated as it is in normal animals and in animals following side-to-side shunt. Other forms of liver damage such as chronic carbon tetrachloride poisoning failed to inhibit the activation of ODC following partial hepatectomy. That the enzyme system is functional in the liver of rats following end-to-side portacaval shunt is shown by significant activation of ODC following injection of growth hormone. The results suggest that there is a critical defect in the synthesis of polyamines following end-to-side portacaval shunts in rats and that this may have a serious import in RNA synthesis or function.
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