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Subcutaneous Ivalon and Dacron implants were placed in dogs. Dacron provoked less cellular reaction, was invaded by vascular connective tissue, and remained as a pliable implant, whereas the Ivalon quickly became calcified. Silastic catheters with Dacron subcutaneous and preperitoneal cuffs were placed in dogs, rabbits, and normal and uremic human subjects. Except for infection of the exit site in dogs, similar histologic changes were found in all groups. By five weeks, the superficial tunnel was lined by squamous epithelium to the level of the subcutaneous Dacron cuff and both cuffs were stabilized by vascular connective tissue. Despite minimal catheter care, infection of the sinus tract was not seen in rabbits or man over prolonged periods.
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Received in revised form: April 3, 1970
Received: March 25, 1970
© 1971 Published by Elsevier Inc.