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Abstract
A new liver perfusion preservation system has been described that provides wide flexibility
in altering the many factors that may contribute to maintained viability of an excised
organ. Mechanical regulation of flow, pulse profile, and pressure through two separate
collapsible silicone rubber pumps (hepatic artery and portal vein) result in ability
to utilize an erythrocyte-containing perfusate. Addition of adenosine triphosphate
(ATP) successfully reversed some of the evidence of cellular damage (potassium leak
and oxygen and glucose utilization) but did not provide sufficient viability to permit
successful orthotopic transplant of the liver perfused for 24 hours. Monitoring Po2 within the liver substance was more sensitive than measurement of surface pH in the
detection of hypoperfusion.
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Article info
Publication history
Accepted:
April 17,
1972
Footnotes
☆Supported by grants from the John A. Hartford Foundation, Inc., and the United States Public Health Service (Grant No. 2 RO1 AM12126).
Identification
Copyright
© 1972 Published by Elsevier Inc.
