Advertisement
Surgery
Advanced searchSave search
Society of University Surgeons| Volume 74, ISSUE 2, P190-197, August 1973

The immunogenetics of the major histocompatibility chromosomal region in man

  • H.F. Seigler
    Correspondence
    Reprint requests: Dr. H. F. Seigler, Box 3052, Duke University Medical Center, Durham, N. C. 27710.
    Affiliations
    From the Department of Surgery and Division of Immunology, Duke University Medical Center Durham, N. C., U.S.A.

    From the Durham Veterans Administration Hospital, Durham, N. C., U.S.A.
    Search for articles by this author
  • F.E. Ward
    Affiliations
    From the Department of Surgery and Division of Immunology, Duke University Medical Center Durham, N. C., U.S.A.

    From the Durham Veterans Administration Hospital, Durham, N. C., U.S.A.
    Search for articles by this author
  • D.B. Amos
    Affiliations
    From the Department of Surgery and Division of Immunology, Duke University Medical Center Durham, N. C., U.S.A.

    From the Durham Veterans Administration Hospital, Durham, N. C., U.S.A.
    Search for articles by this author
  • D.L. Stickel
    Affiliations
    From the Department of Surgery and Division of Immunology, Duke University Medical Center Durham, N. C., U.S.A.

    From the Durham Veterans Administration Hospital, Durham, N. C., U.S.A.
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:0039606073900524
The immunogenetics of the major histocompatibility chromosomal region in man
Previous ArticleLong-term functional success following freezing of canine kidneys
Next ArticleStroma-free hemoglobin. I. Preparation and observations on in vitro changes in coagulation
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The major histocompatibility locus in man has been named HL-A and the mixed lymphocyte reaction (MLC) has been felt to be an in vitro measure of the locus. In this report we propose a more complex histocompatibility system and term this the HL-1 chromosomal region. Results suggest that the MLC locus is linked to HL-A and not a product of the HL-A locus itself. Studies in a family in which recombination between the genes determining the antigens of the first and second HL-A loci were observed suggested that the locus controlling this reaction was closely linked to the second HL-A locus; differences involving second-series antigens provoked strong stimulation but first-locus antigenic differences did not. Linkage of immune response genes (Ir) is suggested by the correlation of HL-A with mean skin allograft survival times (MST) in families. The skin graft survival times were not always predictable by the degree of MLC stimulation. The absence of absolute correlation of allograft survival with either HL-A or MLC suggests that a genetic factor (Ir) linked to HL-A rather than HL-A itself might provide primary control of delayed-type hypersensitivity and that HL-A, MLC, and Ir comprise a series of closely linked loci that make up the majority transplantation region in man—HL-1.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Albertini R.
        • Bach F.
        Quantitative assay of antigenic disparity at HL-A—The major histocompatibility locus in man.
        J. Exp. Med. 1968; 128: 639
        • Amos D.B.
        • Bashir H.
        • Boyle W.
        • Mac-Queen J.
        • Tiilikainen A.
        A simple microcytotoxicity test.
        Transplantation. 1969; 7: 220
        • Amos D.B.
        • Seigler H.F.
        • Simmons R.L.
        • Yunis E.J.
        HL-A typing, mixed leukocyte reactivity and skin graft survival in a family with a recombinant at the HL-1 chromosomal region (major transplantation region).
        Transplantation. 1973; 15: 435
        • Amos D.B.
        • Seigler H.F.
        • Southworth J.G.
        • Ward F.E.
        Skin graft rejection between subjects genotyped for HL-A.
        Transplant. Proc. 1969; 1: 342

      5. Amos, D. B., et al.: Unpublished data.

        • Bach F.H.
        • Amos D.B.
        Hu-1: Major histocompatibility locus in man.
        Science. 1967; 156: 1506
        • Ceppellini R.
        • Curtoni E.S.
        • Mattiuz P.L.
        • Leigheb B.
        • Vissetti M.
        • Colombi A.
        Survival of test skin grafts in man: Effect of genetic relationship and of blood groups incompatibility.
        in: Seventh International Transplantation Conference. Ann. N. Y. Acad. Sci. 129. 1966: 421
        • Dausset J.
        • Walford R.
        • Colombani J.
        • Legrand L.
        • Feingold N.
        • Boyce A.
        • Rapaport F.
        The HL-A system sub-loci and their importance in transplantation.
        Transplant. Proc. 1969; 1: 331
        • Dick H.M.
        • Briggs J.D.
        • Wood R.F.M.
        • Bell P.R.F.
        Severe rejection of an HL-A identical sibling renal transplant.
        Tissue Antigens. 1972; 2: 345
        • Dupont B.
        • Staub-Neilsen L.
        • Svejgaard A.
        Relative importance of 4 and LA loci in determining MLR response.
        Lancet. 1971; 2: 1336
        • Eijsvoogel V.P.
        • Ria du Bios
        • Melief C.J.M.
        • Zeylemaker W.P.
        • Roat-Koning L.
        • de Groat-Koog L.
        Lymphocyte activation and destruction in vitro in relation to MLC and HL-A.
        Transplant. Proc. 1973; 5: 415
      12. Histocompatibility testing.
        in: Dausset J. Bodmer W.F. Fifth International Histocompatibility Testing Workshop. 1972 (In press)
        • Kissmeyer-Neilsen F.
        • Svejgaard A.
        • Hauge M.
        The HL-A system defined with lymphocytotoxic and platelet antibodies in relation to kidney transplantation.
        Transplant. Proc. 1969; 1: 356

      14. Klein, J.: The immunogenetics of histocompatibility with special reference to the H-2 locus, Transplant. Proc. In press.

        • Klein J.
        • Shreffler D.C.
        Evidence supporting a two-gene model for the H-2 histocompatibility system of the mouse.
        J. Exp. Med. 1972; 135: 924
        • Koch C.T.
        • Frederiks E.
        • Eijsvoogel V.P.
        • van Rood J.J.
        Mixed lymphocyte culture and skin graft data in unrelated HL-A identical individuals.
        Lancet. 1971; 2: 1334
        • Lundgren G.
        • Magnusson G.
        • Moller E.
        • Nordenstam H.
        • Werner B.
        • Westberg G.
        Rejection of an HL-A identical renal transplant.
        Tissue Antigens. 1972; 2: 32
        • Oliver R.T.D.
        • Sachs J.A.
        • Fistenstein H.
        Influence of HL-A matching, antigenic strength and immune responsiveness on outcome of 349 cadaver renal grafts.
        Lancet. 1972; (Dec. 30): 7792
        • Plate J.M.
        • Ward F.E.
        • Amos D.B.
        The mixed leukocyte culture response between HL-A identical siblings.
        in: Terasaki P. Histocompatibility testing. Munksgaard, Copenhagen1970: 531
        • Seigler H.F.
        • Amos D.B.
        • Ward F.E.
        • Southworth J.G.
        • Hattler B.G.
        • Stickel D.L.
        Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts.
        Ann. Surg. 1970; 2: 151
        • Seigler H.F.
        • Ward F.E.
        • Amos D.B.
        • Phaup M.B.
        • Stickel D.L.
        The immunogenicity of human HL-A haplotype as measured by skin graft survival times and mixed leukocyte reactions.
        J. Exp. Med. 1971; 133: 411
        • Svejgaard A.
        • Bratlie A.
        • Hedin P.J.
        • Hogman C.
        • Jersild C.
        • Kissmeyer-Nielsen F.
        • Lindblom B.
        • Lindholm A.
        • Low B.
        • Messeter L.
        • Moller E.
        • Sandberg L.
        • Staub-Nielsen L.
        • Thorsby E.
        The recombination fraction of the HL-A system.
        Tissue Antigens. 1971; 1: 81
        • Van Hoof J.
        • Schippers H.M.A.
        • Van der Steen G.H.
        • Van Rood J.J.
        Efficacy of HL-A matching in Eurotransplant.
        Lancet. 1972; 2: 1385
        • Van Rood J.J.
        • van Leeuwen A.
        • Eernisse J.G.
        • Frederiks E.
        • Bosch L.J.
        Relationship of leukocyte groups to tissue transplantation compatibility.
        Ann. N. Y. Acad. Sci. 1964; 120: 285
        • Ward F.E.
        • Seigler H.F.
        Mixed lymphocyte reactions and skin graft survival in an HL-A recombinant family.
        Transplant. Proc. 1973; 5: 359
        • Yunis E.J.
        • Plate M.
        • Ward F.E.
        • Seigler H.F.
        • Amos D.B.
        Anomalous MLR responsiveness among siblings.
        Transplant. Proc. 1971; 3: 118

      Article info

      Footnotes

      ☆This work was supported in part by National Institutes of Health Grant AM 13084, by Veterans Administration Surgical Research Funds, and by a grant (RR-30) from the General Clinical Research Centers Program of the Division of Research Resources, National Institutes of Health.

      ☆☆Presented at the Thirty-fourth Annual Meeting of the Society of University Surgeons, New Orleans, La., Feb. 8–10, 1973.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606073900524

      Copyright

      © 1973 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX