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Society of University Surgeons| Volume 74, ISSUE 2, P223-234, August 1973

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Altered insulin and glucose metabolism produced by epinephrine during hemorrhagic shock in the adrenalectomized primate

  • J.M. Hiebert
    Correspondence
    Reprint requests: John M. Hiebert, M.D., University Hospital, Department of Surgery, 750 Harrison Ave., Boston, Mass. 02118.
    Footnotes
    Affiliations
    From the Trauma Center, Boston University Medical Center Boston, Mass., U.S.A.

    From the E. P. Joslin Research Laboratory, and the Joslin Diabetes Foundation, Inc., Boston, Mass., U.S.A.
    Search for articles by this author
  • N. Sixt
    Affiliations
    From the Trauma Center, Boston University Medical Center Boston, Mass., U.S.A.

    From the E. P. Joslin Research Laboratory, and the Joslin Diabetes Foundation, Inc., Boston, Mass., U.S.A.
    Search for articles by this author
  • J.S. Soeldner
    Affiliations
    From the Trauma Center, Boston University Medical Center Boston, Mass., U.S.A.

    From the E. P. Joslin Research Laboratory, and the Joslin Diabetes Foundation, Inc., Boston, Mass., U.S.A.
    Search for articles by this author
  • R.H. Egdahl
    Affiliations
    From the Trauma Center, Boston University Medical Center Boston, Mass., U.S.A.

    From the E. P. Joslin Research Laboratory, and the Joslin Diabetes Foundation, Inc., Boston, Mass., U.S.A.
    Search for articles by this author
  • Author Footnotes
    ∗ Trainee in Academic Surgery, University Hospital and Boston University Medical Center.
DOI:https://doi.org/10.5555/uri:pii:0039606073900561
Altered insulin and glucose metabolism produced by epinephrine during hemorrhagic shock in the adrenalectomized primate
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      Abstract

      Bilaterally adrenalectomized rhesus monkeys undergoing hemorrhagic shock were given glucose tolerance tests; insulin secretory rates (ISR) and rate of glucose disappearance (Kg) were calculated. Effects of epinephrine and simultaneously infused alpha- or beta-adrenergic blocking agents on ISR and Kg were evaluated. The effect of steroids on ISR and glucose tolerance during shock was also studied. ISR after glucose administration in shock was significantly depressed by epinephrine. ISR returned to normal levels with alpha- but not with beta-adrenergic blockade. Glucose intolerance during shock was observed in all epinephrine-infused animals with or without adrenergic blocking agents and was dose related. Our data suggest: (1) Epinephrine alters insulin and glucose metabolism during shock in at least two separate ways; one involves insulin secretion and the other involves a peripheral effect with several possible components. (2) The effects of epinephrine are dose related. (3) The inhibitory effects of epinephrine on ISR are negated by alpha blockers, whereas no change in glucose disappearance was noted during simultaneous epinephrine and alpha blocker administration. This further suggests a quantitative and perhaps qualitatively different role for epinephrine on glucose metabolism and insulin secretion from the pancreas.
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      Article info

      Footnotes

      ☆Supported in part by United States Army Contract No. DADA 17:67-C-7149, National Institutes of Health Trauma Center Grant No. GM-17366, National Institutes of Health Academic Training Grant No. GM-01498, and United States Public Health Service Grant No. AM 09748.

      ☆☆Presented at the Thirty-fourth Annual Meeting of the Society of University Surgeons, New Orleans, La., Feb. 8–10, 1973.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606073900561

      Copyright

      © 1973 Published by Elsevier Inc.

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