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Abstract
Techniques developed for the in vivo study of cellular physiology have been applied
to hemorrhagic shock in primates. A technique of measuring skeletal muscle transmembrane
resting and action potentials was correlated with an analysis of fluid and electrolytes
in skeletal muscle and extracellular fluid. The data obtained indicate a marked diminution
in muscle extracellular water and an increase in intracellular sodium and water during
shock. There was an associated decrease in resting membrane potential, a decrease
in amplitude of the action potential, and prolongation of both the repolarization
and depolarization time. In addition, there was a decrease of muscle intracellular
potassium concentration during shock. Resuscitation reversed these changes acutely
except for repolarization time which remained prolonged with a persistent depression
of measured intracellular sodium combined with an expanded ECW. This study confirms
alterations in cellular membranes in vivo during hemorrhagic shock. Further studies
are in progress to delineate the precise changes in cellular transport mechanisms.
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Article info
Footnotes
☆This work was supported in part by National Institutes of Health Special Fellowship 18470.
☆☆Presented at the Thirty-fourth Annual Meeting of the Society of University Surgeons, New Orleans, La., Feb. 8–10, 1973.
Identification
Copyright
© 1973 Published by Elsevier Inc.
