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Society of University Surgeons| Volume 74, ISSUE 2, P251-262, August 1973

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The respiratory distress syndrome: A review

  • F.William Blaisdell
    Correspondence
    Reprint requests: Dr. F. William Blaisdell, Department of Surgery, San Francisco General Hospital, San Francisco, Calif. 94110.
    Affiliations
    From the Trauma Service of the University of California, Departments of Surgery and Anesthesiology at San Francisco General Hospital, San Francisco, Calif., U.S.A.
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  • Richard M. Schlobohm
    Affiliations
    From the Trauma Service of the University of California, Departments of Surgery and Anesthesiology at San Francisco General Hospital, San Francisco, Calif., U.S.A.
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DOI:https://doi.org/10.5555/uri:pii:0039606073900597
The respiratory distress syndrome: A review
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      Abstract

      The pathologic changes of respiratory insufficiency follow a predictable pattern: microemboli filling small pulmonary arterioles, congestion, interstitial edema, hemorrhage, hyaline membranes, bronchopneumonia, then pulmonary fibrosis. The exact etiology of the syndrome is still controversial. The pulmonary damage may result from a noxious agent in the blood. Thromboeomboli have been the easiest to document and would explain the changes in vascular permeability and the pulmonary damage. Prevention of respiratory failure consists of prompt resuscitation from shock, removal of damaged tissue, and prevention of hypoventilation, atelectasis, embolism, and infection. The principal feature in treatment consists of positive-pressure ventilation. If progressive pulmonary deterioration occurs on intermittent positive-pressure ventilation, positive end-expiratory pressure may be indicated—the major advance in treatment in the past two years.
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      Article info

      Footnotes

      ☆Supported by United States Public Health Service Trauma Program Project Grant GM 18470.

      ☆☆Presented at the Thirty-fourth Annual Meeting of the Society of University Surgeons, New Orleans, La., Feb. 8–10, 1973.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606073900597

      Copyright

      © 1973 Published by Elsevier Inc.

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