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Abstract
Studies in dogs demonstrated that injuries produced by Fogarty catheterization, electricity,
and crushing were different, as evaluated by the interface potential and scanning
electron microscope. Fogarty catheterization destroyed the integrity of the vascular
potential, evulsing the intima from underlying media usually with much platelets and
cells sticking to underlying collagen and causing progressive thrombosis. The positively
charged electrode caused much destruction, “building block” surface thrombosis, and
obvious geographical destruction. These results were more or less reversed by heparin
so that the normal rugae were still discernible. Crushing physically destroyed the
integrity of blood vessel walls, markedly reducing normal negative interface potentials.
The damaged crevices filled in by what appears to be a smooth platelet fibrin layer.
Thrombi under each condition have both different appearance and different cellular
structure. All of this is reversed by heparin and promoted by protamine. The thrombotic
response to injury is modulated by the mechanism of damage, the order of magnitude
of injury, and the coagulant status of the blood and the vascular tree. The effects
of injury are modified by heparin and other anticoagulant agents. In the face of continuing
blood flow, their application appear to limit the effects of injury.
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Article info
Footnotes
☆Supported in part by Grants-in-Aid from the Cardiovascular Society, Inc., and the Sawyer Foundation.
☆☆Presented at the Thirty-fourth Annual Meeting of the Society of University Surgeons, New Orleans, La., Feb. 8–10, 1973.
Identification
Copyright
© 1973 Published by Elsevier Inc.
