Original communication| Volume 75, ISSUE 2, P203-212, February 1974

Elevation in host splenic and in allograft parenchymal and capsular histidine decarboxylase activity and weights following renal allografting in rats

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      An elevation in host splenic and in allograft parenchymal and capsular histidine decarboxylose (HDC) activity and weights occurred following renal allografting in 54 rats in comparison with normal values and with those found after renal isografting. Splenic HDC elevation peaked at four days after allografting, whereas renal allograft parenchymal HDC activity did not become elevated significantly until the second five days after grafting and did not reach its maximum elevation until ten days after grafting. A steady increase in capsular weight occurred after grafting. Capsular elevation in HDC activity was biphasis with major elevations at 24 hours and ten days. The findings suggest a role of importance for HDC activity in both the afferent and efferent arcs of the immune response to organ allografting. The difference in renal allograft capsular and parenchymal HDC activity may reflect a difference in the response of non-sensitized animals to allografted tissue in contact with antigenically foreign tissue over a wide surface area for bulk in comparison with that exposed only to the antigenically foreign cellular elements of circulating blood.
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        • Kahlson G.
        New approaches to the physiology of histamine.
        Perspect. Biol. Med. 1962; 5: 179
        • Lee S.
        An improved technique of renal allografting in the rat.
        Surgery. 1967; 61: 771
        • Majno G.
        • Palade G.E.
        • Schoefl G.I.
        Studies on inflammation. II. The site of action of histamine and serotonin along the vascular tree: A topographical study.
        J. Biophys. Biochem. Cytol. 1961; 11: 607
        • Moore T.C.
        • Chang J.
        Urinary histamine excretion in the rat following skin homografting and autografting.
        Ann. Surg. 1968; 167: 232
      1. Moore, T. C., and Jaffe, B. M.: Unpublished data.

        • Moore T.C.
        • Schayer R.W.
        Histidine decarboxylase activity of autografted and allografted rat skin.
        Transplantation. 1969; 7: 99
        • Moore T.C.
        • Schayer R.W.
        Histidine decarboxylase activity of the rat spleen following skin allografting.
        Ann. Surg. 1970; 171: 609
        • Moore T.C.
        • Thompson D.P.
        • Hayes M.
        Correlation of renal blood flow indices and histamine metabolism data after canine renal allografting.
        Arch. Surg. 1970; 101: 45
        • Moore T.C.
        • Cleveland R.J.
        • Thompson D.P.
        • Nelson R.J.
        Vasoactive amine metabolism following canine and human heart transplantation.
        Ann. Surg. 1971; 174: 51
        • Moore T.C.
        • Lemmi C.A.E.
        • Orlando J.C.
        • Pinkerton W.
        Correlation of splenic histidine decarboxylase activity and antibody formation following SRBC immunization.
        Transplantation. 1971; 11: 347
        • Moore T.C.
        • Thompson D.P.
        • Glassock R.J.
        Elevation in urinary and blood histamine following clinical renal transplantation.
        Ann. Surg. 1971; 173: 381
      2. Moore, T. C., Sinclair, M. C., and Lemmi, C. A. E.: Elevation of rat plasma kallikrein activity following renal allografting, Am. J. Surg. In press.

        • Schayer R.W.
        Formation and binding of histamine by rat tissues in vitro.
        Am. J. Physiol. 1956; 187: 63
        • Schayer R.W.
        Role of histamine in Freund's adjuvant action (abstract).
        in: ed. 2. Fed. Proc. 29. 1970: 617