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Abstract
An elevation in host splenic and in allograft parenchymal and capsular histidine decarboxylose
(HDC) activity and weights occurred following renal allografting in 54 rats in comparison
with normal values and with those found after renal isografting. Splenic HDC elevation
peaked at four days after allografting, whereas renal allograft parenchymal HDC activity
did not become elevated significantly until the second five days after grafting and
did not reach its maximum elevation until ten days after grafting. A steady increase
in capsular weight occurred after grafting. Capsular elevation in HDC activity was
biphasis with major elevations at 24 hours and ten days. The findings suggest a role
of importance for HDC activity in both the afferent and efferent arcs of the immune
response to organ allografting. The difference in renal allograft capsular and parenchymal
HDC activity may reflect a difference in the response of non-sensitized animals to
allografted tissue in contact with antigenically foreign tissue over a wide surface
area for bulk in comparison with that exposed only to the antigenically foreign cellular
elements of circulating blood.
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Article info
Publication history
Received:
October 10,
1973
Footnotes
☆Supported by grants from The John A. Hartford Foundation, Inc., National Institutes of Health (AM-10373-01), and The Los Angeles County Heart Association.
Identification
Copyright
© 1974 Published by Elsevier Inc.
