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Original communication| Volume 75, ISSUE 2, P220-227, February 1974

Effect of adenosine triphosphate-magnesium chloride administration in shock

  • Irshad H. Chaudry
    Correspondence
    Reprint requests: Dr. Irshad H. Chaudry, Dept. of Biochemistry, Concordia University, 1455 de Maisonneuve, Montreal, Canada.
    Affiliations
    From the Division of Cell Physiology, Department of Surgery, Washington University School of Medicine St. Louis, Mo., USA

    From the Jewish Hospital of St. Louis, St. Louis, Mo., USA
    Search for articles by this author
  • Mohammed M. Sayeed
    Affiliations
    From the Division of Cell Physiology, Department of Surgery, Washington University School of Medicine St. Louis, Mo., USA

    From the Jewish Hospital of St. Louis, St. Louis, Mo., USA
    Search for articles by this author
  • Arthur E. Baue
    Affiliations
    From the Division of Cell Physiology, Department of Surgery, Washington University School of Medicine St. Louis, Mo., USA

    From the Jewish Hospital of St. Louis, St. Louis, Mo., USA
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:0039606074903055
Effect of adenosine triphosphate-magnesium chloride administration in shock
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      Abstract

      Hemorrhagic shock was produced in conscious rats by bleeding the animals to a mean arterial pressure of 40 mm. Hg which was maintained for Math Eq hours. The animals were then treated by various means. Intravenous infusion of ATP-MgCl2 (adenosine triphosphate-magnesium chloride) before, during, or after a prolonged period of shock proved beneficial in the treatment of shock whereas ATP alone was beneficial only when given in early shock. Animals receiving ATP-MgCl2 had an 83 percent survival rate, whereas those receiving ATP alone or ADP-(adenosine diphosphate-), AMP-(adenosine monophosphate-), or adenosine-MgCl2 or Ringer's lactate had 100 percent mortality rate when treated after prolonged shock. The beneficial effect of high-energy phosphate compounds was specific to ATP-MgCl2. The effect of ATP-MgCl2 does not appear to be through vasodilatation alone since more potent vasodilating agents, such as ADP or AMP failed to produce any beneficial effect.
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      Article info

      Publication history

      Received: October 10, 1973

      Footnotes

      ☆This investigation was supported by United States Army Contract No. DADA-17-69-9165 and United States Public Health Service Grant No. 5 RO 1 HL 12278-05.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606074903055

      Copyright

      © 1974 Published by Elsevier Inc.

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