Original communication| Volume 75, ISSUE 2, P243-252, February 1974

Investigations of the enterobiliary metabolism of lecithin

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      Simultaneous sampling in pigs of thoracic duct lymph, portal and vena caval blood, and common duct bile after intestinal administration of 14C-lecithin showed a rapid and progressive rise in the concentration of radioactivity in lipid fractions of the bile extracts. Analyses of the distribution of lipid radioactivity demonstrated triglycerides to be the major form of transport in lymph and blood, whereas 70 percent of the radioactivity in bile was in the lecithin (phosphatidyl-choline) fraction eight hours after isotope administration. The data demonstrate that dietary lecithin contributes to biliary lecithin secretion probably by way of its intestinal hydrolytic products. Animals with intact thoracic ducts showed the same cumulative rise in biliary lipid radioactivity as did those with thoracic duct fistulas, suggesting that the intestinal precursors of biliary lecithin synthesis may reach the liver by a route other than the thoracic duct.
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