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Original communication| Volume 75, ISSUE 2, P243-252, February 1974

Investigations of the enterobiliary metabolism of lecithin

DOI:https://doi.org/10.5555/uri:pii:0039606074903092
Investigations of the enterobiliary metabolism of lecithin
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      Abstract

      Simultaneous sampling in pigs of thoracic duct lymph, portal and vena caval blood, and common duct bile after intestinal administration of 14C-lecithin showed a rapid and progressive rise in the concentration of radioactivity in lipid fractions of the bile extracts. Analyses of the distribution of lipid radioactivity demonstrated triglycerides to be the major form of transport in lymph and blood, whereas 70 percent of the radioactivity in bile was in the lecithin (phosphatidyl-choline) fraction eight hours after isotope administration. The data demonstrate that dietary lecithin contributes to biliary lecithin secretion probably by way of its intestinal hydrolytic products. Animals with intact thoracic ducts showed the same cumulative rise in biliary lipid radioactivity as did those with thoracic duct fistulas, suggesting that the intestinal precursors of biliary lecithin synthesis may reach the liver by a route other than the thoracic duct.
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      Article info

      Publication history

      Accepted: October 10, 1973

      Footnotes

      ☆Supported by grants from The John A. Hartford Foundation, Inc., New York, N. Y. and The U. S. Public Health Service (FR-05354).

      ☆☆Portions of this study were presented at the Annual Meeting of the American Gastroenterological Association, May, 1971,8 Surgical Forum of American College of Surgeons, Oct., 1971,26 and The Deuel Lipid Conference, March, 1972.25

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606074903092

      Copyright

      © 1974 Published by Elsevier Inc.

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