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Abstract
The secretion of circulating labeled cholesterol by a total biliary fistula, by the
isolated upper half of the small intestine, and by the isolated lower half of the
small intestine was measured in 21 anesthetized rabbits over an average time of 13
hours. From the secreted radioactivity, ratios were calculated and the three key average
radioactivity excretion ratios were: bile counts per minute (cpm)/combined total number
of counts per minute (bile counts per minute + upper small intestinal counts per minute
+ lower small intestinal counts per minute), 0.5470; bile counts per minute/total
number of small intestinal counts per minute, 1.4948; and jejunal-ileal counts per
minute/distal ileal counts per minute, 1.6031. The measured average jejunal-ileal/
distal ileal length ratio was 1.338. It is concluded that in the rabbit under the
acute conditions of this experiment: (1) the cholesterol that is secreted in the bile
is ![Math Eq]()
times the amount secreted by the small intestinal mucosa. (2) Small bowel mucosal
cholesterol secretion, on the basis of comparison of the jejunal-ileal/distal ileal
counts per minute and length ratios, does not appear to be localized to either the
upper or the lower half of the small intestine. (3) Bowel mucosal cholesterol secretion
is independent of the presence of bile salts in the intestinal lumen.
times the amount secreted by the small intestinal mucosa. (2) Small bowel mucosal
cholesterol secretion, on the basis of comparison of the jejunal-ileal/distal ileal
counts per minute and length ratios, does not appear to be localized to either the
upper or the lower half of the small intestine. (3) Bowel mucosal cholesterol secretion
is independent of the presence of bile salts in the intestinal lumen.To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
October 10,
1973
Footnotes
☆This work supported by a grant from the National Heart and Lung Institute HL11901-01, a grant from the Minnesota Heart Association, and a grant from the Graduate School of the University of Minnesota.
Identification
Copyright
© 1974 Published by Elsevier Inc.
