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Original communication| Volume 75, ISSUE 4, P487-495, April 1974

The interaction of glucagon and glucose on cardiorespiratory variables in the critically ill patient

DOI:https://doi.org/10.5555/uri:pii:0039606074903249
The interaction of glucagon and glucose on cardiorespiratory variables in the critically ill patient
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      Abstract

      The effect of glucagon on hemodynamic and oxygen transport was studied in 11 severely stressed surgical patients. When these responses were evaluated in relation to the patients' prior intravenous therapy, those patients who have received increased metabolic substrate (50 percent glucose) had, in general, greater and more consistent responses to glucagon infusion. It is suggested that exogenous glucose supplies the metabolic substrates necessary for the inotropic effect of glucagon. It is also suggested that the variability in response observed clinically with this hormone may be related to the carbohydrate availability. Since critically ill patients are frequently undernourished, therapeutic use of glucagon should be accompanied by adequate caloric intake.
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      Article info

      Publication history

      Accepted: January 28, 1974

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606074903249

      Copyright

      © 1974 Published by Elsevier Inc.

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