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Absorption studies of short and long chain fatty acids (lauric acid and oleic acid) were performed in jejunal Thiry-Vella loops, autografts and untreated allografts. Lauric acid absorption in jejunal allografts correlated well with progressive morphologic signs of rejection, thus suggesting its usefulness in predicting intestinal allograft rejection. Oleic acid was not absorbed in the absence of lymphatic regeneration. The first appearance of oleic acid absorption in autografts (two to four weeks) was related to regeneration of the lymphatic vessels as shown by lymphangiography. It is therefore suggested that oleic acid absorption may ultimately serve as a test of functional capacity of regenerating lymphatic vessels of intestinal allografts.
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Accepted: February 6, 1974
© 1974 Published by Elsevier Inc.