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Original communication| Volume 75, ISSUE 4, P503-507, April 1974

Experimental cancer immunotherapy using a neuramimidase-treated non-viable frozen tumor vaccine

DOI:https://doi.org/10.5555/uri:pii:0039606074903262
Experimental cancer immunotherapy using a neuramimidase-treated non-viable frozen tumor vaccine
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      Abstract

      Firmly established tumors in syngeneic mice will regress if the host is challenged with living tumor cells which have been exposed to Vibrio cholerae neuraminidase (VCN) in vitro. The present study demonstrates that rapid freezing of the VCN-treated tumor challenge at −95 ° C. and storage at −70 ° C. does not interfere with its immunoregressive potency but does prevent regrowth of the tumor cells from the challenging vaccine. The clinical potential of this finding is discussed.
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      Article info

      Publication history

      Accepted: January 29, 1974

      Footnotes

      ☆Supported by Grant No. CA 11605 from the United States Public Health Service and Grant No. IM-20A from the American Cancer Society.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606074903262

      Copyright

      © 1974 Published by Elsevier Inc.

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