Original communication| Volume 75, ISSUE 4, P517-527, April 1974

An experimental study of the antral gastrin mechanism

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      Over a period of four years, experiments were carried out in 120 dogs in which the gastric antral mucosa was subjected on a chronic basis to nine different environmental conditions in three general categories of influence: antral “stimulation,” antral “inhibition,” and “neutral” (neither antral stimulation nor inhibition). To substantiate the endocrine function of the antrum, the influence of the antral mucosal environment on antral gastrin release was measured directly by repeated serum gastrin concentrations and indirectly by gastric acid concentrations and the incidence of ulceration. The results show that the antrum of the dog is responsive to chronic experimental stimulation by distention and by alkaline secretions of the colon, duodenum, and gallbladder, as evidenced by significant elevations of serum gastrin concentrations (p < 0.001) and by an increase in the incidence of acid-peptic ulceration. When the antrum is in juxtaposition to acid-secreting gastric mucosa, no significant increases in serum gastrin content occur; furthermore, if the antral mucosa is chronically exposed to histamine-provoked acid hypersecretion, significant reductions in serum gastrin content are observed (p = 0.025), suggesting inhibition of antral gastrin release. The antral mucosa is dynamically responsive to experimental changes in its environment without evidence of fatigue within the observed experimental period of six months.
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