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Chronic salt-loading is known to protect rats from glycerol-induced hemaglobinuric renal failure. Experiments with transplantation in salt-drinking and H2O-drinking rats demonstrated that chronic salt-loading of both donor and recipient are necessary to protect against acute tubular necrosis from transplant ischemia time. Plasma volume expansion at the last minute will not provide this protection from renal failure. It appears, however, that a kidney so protected and given glycerol cannot tolerate the added ischemic insult of a transplant. Chronic increase in salt intake, insofar as it does not produce dangerous hypertension, may be useful for patients undergoing elective major renal vascular procedures.
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Accepted: July 18, 1973
© 1974 Published by Elsevier Inc.