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Original communication| Volume 79, ISSUE 2, P152-160, February 1976

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Computer processed 99mTc-DTPA studies of renal allotransplants

  • Dan G. Pavel
    Correspondence
    Reprint requests: Dan G. Pavel, M.D., Department of Nuclear Medicine. University of Illinois Hospital, 840 South Wood St., Chicago, Ill. 60612.
    Affiliations
    From the Departments of Surgery and Nuclear Medicine, Northwestern University Medical Center Chicago, Ill., USA

    From the Veterans Administration Research Hospital, Chicago, Ill., USA
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  • Bryan R. Westerman
    Affiliations
    From the Departments of Surgery and Nuclear Medicine, Northwestern University Medical Center Chicago, Ill., USA

    From the Veterans Administration Research Hospital, Chicago, Ill., USA
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  • John J. Bergan
    Affiliations
    From the Departments of Surgery and Nuclear Medicine, Northwestern University Medical Center Chicago, Ill., USA

    From the Veterans Administration Research Hospital, Chicago, Ill., USA
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  • Barry D. Kahan
    Affiliations
    From the Departments of Surgery and Nuclear Medicine, Northwestern University Medical Center Chicago, Ill., USA

    From the Veterans Administration Research Hospital, Chicago, Ill., USA
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:0039606076902816
Computer processed 99mTc-DTPA studies of renal allotransplants
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      Abstract

      In order to refine the diagnostic possibilities of the radionuclide renal study in transplanted patients and to compensate for the nonspecificity of the 131I-hippuran study in some situation, 99mTc-DTPA was used simultaneously for imaging and time-activity curves. For these curves to be significant, appropriate background subtraction had to be made with a simple computer-processing method. The results obtained have shown that it is possible to distinguish marked acute tubular necrosis from milder degrees, thus affording a prognostic index in the immediate postoperative period, when the hippuran data are often nonspecific. Further, the diagnosis and follow-up of acute rejection episodes can be improved by the DTPA processed curves. Although these curves when examined individually do not show a specific pattern for rejection, they may reveal striking evolutionary changes when compared to the previous studies, even when the hippuran curves are unchanged. The physiologic basis for the differences between the two time-activity curves may be related to the differential handling of the two radiopharmaceuticals by the kidney.
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      References

        • Burke G.
        • Halco H.
        Scintillation camera renography in the study of prolonged renal transit time.
        Radiology. 1967; 88: 704
        • Chapman A.
        • Prata M.
        • Gluckman J.C.
        • et al.
        Etude de la fonction renale au cours du premier mois qui suit la transplantation. Renseignements fournis par le radiohippuran.
        J. Urol. Nephrol. 1972; 78: 782
        • DeGrazia A.J.
        • Scheibe O.P.
        • Jackson P.E.
        • et al.
        Clinical applications of a kinetic model of hippurate distribution and renal clearance.
        J. Nucl. Med. 1974; 15: 102
        • Dubovska E.V.
        • Logic J.R.
        • Tauxe W.N.
        • et al.
        Dynamic renal studies in the early post-transplant period.
        in: ed. 4. Dynamic studies with radioisotopes in medicine 1974. Vol. I. International Atomic Energy Agency, Vienna1974
        • Freedman G.S.
        • Schiff M.
        • Zager P.
        • et al.
        The temporal and pathological significance of perfusion failure following renal transplantation.
        Radiology. 1975; 114: 649
        • Hayes M.
        • Moore T.C.
        Early detection of canine renal allograft rejection by reduction in the scan bladder/ kidney isotope intensity ratio.
        Surgery. 1972; 70: 60
        • Hayes M.
        • Taplin C.V.
        • Moore T.C.
        Quantitated scintiphotos in predicting early renal transplant rejection.
        in: Medical radioisotope scintigraphy. ed. 4. Proc. Symp. Monte Carlo, 1972. Vol. II. International Atomic Energy Agency, Vienna1973: 211
        • Hör G.
        • Pabst W.
        • Pfeifer K.J.
        • et al.
        Radionuclides in renal transplantation.
        J. Nucl. Med. 1972; 13: 795
        • Kahan B.D.
        • Tom B.H.
        • Mittal K.K.
        • et al.
        Immunodiagnostic test for transplant rejection.
        Lancet. 1974; 1: 42
        • Klopper J.F.
        • Hauser W.
        • Atkins H.L.
        • et al.
        Evaluation of 99mTc-DTPA for the measurement of glomerular filtration rate.
        J. Nucl. Med. 1972; 13: 107
        • Kountz S.
        Radionuclides and renal transplantation.
        in: Blaufox D.M. Progress in nuclear medicine. Baltimore University Park Press, Baltimore1972: 235 (Chap. 11)
        • Pavel D.G.
        Interpretation of radioisotope renogram changes during acute toxic renal insufficiency due to oxalic acid. An experimental study.
        in: Horst W. Frontiers of nuclear medicine. Springer-Verlag, Berlin1971: 194
        • Pavel D.G.
        • Chanard J.
        Renography in patients with acute renal failure in the polyuric stage.
        in: Blaufox D.M. Funck-Brentano J.-L. Radionuclides in nephrology. Grune & Stratton, Inc, New York1972: 351
        • Pavel D.G.
        • Westerman B.R.
        • Conway J.J.
        A method for improving the accuracy and shortening the generation time of a renogram curve with the scientilation camera.
        J. Nucl. Med. Tech. 1975; 3: 40
        • Pavel D.G.
        • Gheorgheseu B.
        • Lupu I.
        • et al.
        Demonstration of a certain stage of renal tubular insufficiency be means of radioisotope renography.
        in: Timmermans L. Merchie G. Radioisotopes in the diagnosis of diseases of the kidneys. Excerpta Medica Foundation, Amsterdam1969: 422
        • Pavel D.G.
        • Kahan B.D.
        • Quinn J.L.
        • et al.
        Multilateral evaluation of renal transplants with radionuclides.
        in: ed. 4. Dynamic studies with radioisotopes in medicine 1974. Vol. I. International Atomic Energy Agency, Vienna1974: 307
        • Pitts R.F.
        Physiology of the kidney and body fluids.
        in: Year Book Medical Publishers, Inc, Chicago1974: 140
        • Rosenthal L.
        • Mangel R.
        • Lisbona R.
        • et al.
        Diagnostic applications of radiopertechneate and radiohippurate imaging in post-renal transplant complications.
        Radiology. 1974; 111: 347
        • Salvatiera Jr., O.
        • Powell M.R.
        • Price D.C.
        • et al.
        The advantages of 131I-orthoiodohippurate scintiphotography in the management of patients after renal transplantation.
        Ann. Surg. 1974; 180: 336
        • Staab E.V.
        • Whittier F.
        • Patton D.D.
        • et al.
        Early evaluation of cadaver renal allotransplant by means of radionuclide imaging.
        Radiology. 1973; 106: 147
        • Swyngedauw J.
        Nephrogramme de l'hypertendu.
        Ann. Biol. Clin. 1965; 23: 1015
        • Wedeen R.P.
        Autoradiography of hippuran-I125 in rat kidney; the intrarenal basis of the radioisotope renogram.
        in: Timmermans L. Merchie G. Radioisotopes in the diagnosis of diseases of the kidneys. Excerpta Medica Foundation, Amsterdam1969: 461
        • Weiss E.R.
        • Blahd W.H.
        • Winston A.M.
        • et al.
        Scintillation camera in the evaluation of renal transplants.
        J. Nucl. Med. 1970; 11: 69
        • Zum Winkel K.
        • Harbst H.
        • Birendra Das K.
        • et al.
        Applications of radionuclides in renal transplantation.
        in: ed. 4. Semin. Nucl. Med. 4. 1974: 169

      Article info

      Footnotes

      ☆Presented at the First Annual Meeting of the American Society of Transplant Surgeons, Chicago, Ill., May 23, 1975.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606076902816

      Copyright

      © 1976 Published by Elsevier Inc.

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