This paper is only available as a PDF. To read, Please Download here.
The relationship between serum lactic dehydrogenase (SLDH) values and renal allograft rejection was examined in the dog and in man. Nine dogs with renal allografts and four with autografts had similar maximal elevations of SLDH during the first five postoperative days (mean, 420 ± 213 and 433 ± 80 I.U. per liter, respectively). During rejection of the allografts between days 7 and 14 the maximum SLDH was 810 ± 285 I.U. per liter, and in autografts the peak SLDH was 233 ± 22 I.U. per liter (p < 0.01). The isoenzyme pattern of maximum SLDH during rejection was prominent in LDH5 and corresponded with renal tissue LDH isoenzyme composition. In 93 episodes of initial acute human renal allograft rejection reactions, the SLDH peaked above 500 I.U. per liter in 23 cases and remained below 500 I.U. per liter in 70 cases. SLDH levels above 500 I.U. per liter were associated with complete rejection of the kidney in 91 percent of patients and SLDH levels persistently below 500 I.U. per liter corresponded with reversal of rejection reaction in 99 percent of patients (p < 0.01). Marked SLDH elevation is associated with severe, usually complete renal allograft rejection and may be useful in identifying patients with irreversible rejection reactions.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Serum lactic dehydrogenase and human renal allograft failure.Surgery. 1975; 77: 674
- The role of clinical transplantation in patients with end-stage renal disease.Transplant. Proc. 1973; 5: 793
- The quantitative colorimetric determination of lactic dehydrogenase at 400–500 nm.Sigma Tech. Bull. No. 500. Aug., 1974;
- Lactic dehydrogenase activity of dog plasma and urine following renal injury.in: ed. 4. Surg. Forum. 9. 1958: 65
- Diagnostic enzymology.Lea & Febiger, Publishers, Philadelphia1970
- Clinical transplantation—an overview.Transplant. Proc. 1973; 5: 59
- Renal infarction. Elevation of serum and urinary lactic dehydrogenase (LDH).Arch. Intern. Med. 1968; 121: 87
- Diagnosis and management of rejection in allografted kidneys.Transplant. Proc. 1971; 3: 287
- The interpretation of lactate dehydrogenase isoenzyme patterns.Clin. Lab. Bull., U. Texas Med. Br. 1973; 3 (Feb.)
- Lactate dehydrogenase isoenzyme patterns. Meaning and value.Lab. Med. 1973; 53: 172
- Serum and urinary lactic dehydrogenase in patients with renal homotransplantation.Surgery. 1964; 56: 283
- The diagnostic value of LDH isoenzymes in clinical medicine.in: ed. 4. Clinical profile. Vol. 1. Beckman Instruments, Inc, Fullerton, Calif1968
☆Presented at the First Annual Meeting of the American Society of Transplant Surgeons, Chicago, Ill., May 23, 1975.
© 1976 Published by Elsevier Inc.