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Abstract
The relationship between serum lactic dehydrogenase (SLDH) values and renal allograft
rejection was examined in the dog and in man. Nine dogs with renal allografts and
four with autografts had similar maximal elevations of SLDH during the first five
postoperative days (mean, 420 ± 213 and 433 ± 80 I.U. per liter, respectively). During
rejection of the allografts between days 7 and 14 the maximum SLDH was 810 ± 285 I.U.
per liter, and in autografts the peak SLDH was 233 ± 22 I.U. per liter (p < 0.01).
The isoenzyme pattern of maximum SLDH during rejection was prominent in LDH5 and corresponded with renal tissue LDH isoenzyme composition. In 93 episodes of initial
acute human renal allograft rejection reactions, the SLDH peaked above 500 I.U. per
liter in 23 cases and remained below 500 I.U. per liter in 70 cases. SLDH levels above
500 I.U. per liter were associated with complete rejection of the kidney in 91 percent
of patients and SLDH levels persistently below 500 I.U. per liter corresponded with
reversal of rejection reaction in 99 percent of patients (p < 0.01). Marked SLDH elevation
is associated with severe, usually complete renal allograft rejection and may be useful
in identifying patients with irreversible rejection reactions.
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References
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Article info
Footnotes
☆Presented at the First Annual Meeting of the American Society of Transplant Surgeons, Chicago, Ill., May 23, 1975.
Identification
Copyright
© 1976 Published by Elsevier Inc.
