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Abstract
It has been suggested that the liver suppresses the immune response to alloantigen.
This hypothesis was tested utilizing parathyroid implantation into the liver and muscles
of inbred rats. Recipients were parathyroidectomized and, after significant hypocalcemia,
donor parathyroids from minor histoincompatible rats were implanted either in liver
or in thigh hamstring. In one experimental group second-set grafting also was tested.
Graft survivals were evaluated by (1) duration of functional response (DFR), the period
of time during which the serum calcium level remained above the postparathyroidectomy
baseline, (2) maximal response (MR), the proximity of the postimplantation calcium
peak response to the normal preparathyroidectomy calcium level. Parathyroid implants
survived significantly longer in the liver compared to the muscle, only when implanted
across minor histocompatible barriers. It is suggested that the liver may contain
an inhibitor, capable of suppressing the lymphocytes and thus suppressing immune response,
which can be demonstrated when the histocompatibility barrier is weak.
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References
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Article info
Publication history
Accepted:
August 25,
1975
Footnotes
☆Supported by National Institutes of Health Grant No. RO1-AM 17001-02.
Identification
Copyright
© 1976 Published by Elsevier Inc.
