This paper is only available as a PDF. To read, Please Download here.
The blood-prosthesis interaction of the dynamic aortic patch (DAP), an in-series assist device for permanent circulatory support which is implanted in the descending thoracic aorta, was studied in 65 long-term experiments. Periods of postoperative observation with the device inactive or activated ranged from 2 weeks to 22 months. The intravascular surface of the DAP, fabricated of Dacron velour backed by bioelectric polyurethane, displayed various degrees of organization, ranging from a thin fibrin layer to a well organized pseudointima. Activation of the system did not prevent the development of an organized pseudointima. Changes in free-plasma hemoglobin were minimal; platelet count per square millimeter and state of reactivity remained within normal limits. Evidence of renal embolization, attributable to activation of the device, was found in five animals. Frequent lethal complications were aortic rupture and infections of the thoracic cavity originating at the implantation site. Further improvement of the DAP and the techniques of implantation is indicated to insure its efficacy during long-term implantation and activation.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Thrombus formation in implanted blood pumps.Trans. Am. Soc. Artif. Intern. Organs. 1969; 15: 55
- Studies on the dynamic aortic patch and the aorta in clinical trials. Scanning Electron Microscopy.in: IIT Research Institute, Chicago, Ill1973: 443 (Part III)
- Importance of the environment to surface features of cells in situ and in culture. Scanning Electron Microscopy.in: IIT Research Institute, Chicago, Ill1975: 393 (Part I)
- Microscopy as an aid in the evaluation and management of sickle cell anemia.Thromb. Diath. Haemorrh. [Suppl.]. 1973; 53: 193
- Pseudointimal development on microporous polyurethane lattices.Trans. Am. Soc. Artif. Intern. Organs. 1972; 18: 25
- Fetal fibroblasts as a substratum for pseudoendothelial development on prosthetic surfaces.Surgery. 1969; 66: 284
- The effect of citrate on euglobulin methods of estimating fibrinolytic activity.J. Clin. Pathol. 1958; 11: 403
- Assay of factor VII and X.in: ed. 4. Thrombosis and bleeding disorders; a laboratory manual. Academic Press, Inc, New York1971: 199
- In vivo culture of tissue fragments which produce viable cellular linings covered by endothelium (neointima) in impermeable, velour-lined arterial prosthesis, bypass pumps, and valvular prosthesis.Trans. Am. Soc. Artif. Intern. Organs. 1968; 14: 69
- Bioengineering efforts in developing artificial hearts and assistors.Am. J. Surg. 1967; 114: 24
- The serial thrombin time method for measuring fibrinolytic activity of plasma.Nature. 1960; 118: 674
- Long-term in vivo testing of an auxiliary ventricle.Trans. Am. Soc. Artif. Intern. Organs. 1974; 20B: 637
- Partial thromboplastin time techniques.in: ed. 4. Thrombosis and bleeding disorders; a laboratory manual. Academic Press, Inc, New York1971: 76
- Effects of antihemophilic factor on the one-stage clotting test.J. Clin. Lab. Med. 1953; 41: 637
- Development of satisfactory long-term percutaneous leads. Artificial Heart Program.National Heart Institute, Bethesda, Md1970
- Velour vascular prosthesis.Trans. Am. Soc. Artif. Intern. Organs. 1974; 20: 314
- Electrical conductivity: Effect on intravascular performance of foams, velour, flock, and fabric.Trans. Am. Soc. Artif. Intern. Organs. 1974; 20: 91
- Experimental hemodynamic studies with a permanent ventricular assist device.J. Thorac. Cardiovasc. Surg. 1973; 65: 471
- The thromboplastin reagent for the determination of prothrombin.Science. 1940; 92: 112
- Platelet surface activation and inhibition during myocardial infarction.Thromb. Diath. Haemorrh. [Suppl.]. 1970; 42: 215
- Thrombosis in artificial organs.Transplant. Proc. 1971; 3: 1491
- Functions of AC-globulin and lipid in blood clotting.Can. J. Biochem. 1963; 41: 2441
- Electrolour: Achievement of long term vascular tolerance.in: ed. 4. Surg. Forum. 20. 1969: 141
- A dynamic aortic patch as a permanent mechanical auxiliary ventricle: Experimental studies.Surgery. 1969; 66: 875
- Long-term evaluation of plastic arterial substitutes: An experimental study.Surgery. 1964; 55: 165
- Fibrinogen: With special reference to its preparation and certain properties of the product.Arch. Biochem. 1947; 13: 231
- The healing of vascular prosthesis.Surgery. 1965; 57: 319
Accepted: August 25, 1975
☆Supported by Grant HL-13737 from the National Heart and Lung Institute, National Institutes of Health.
© 1976 Published by Elsevier Inc.