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Original communication| Volume 79, ISSUE 2, P193-201, February 1976

Permanent in-series cardiac assistance with the dynamic aortic patch: Blood-prosthesis interaction in long-term canine experiments

  • W. Schraut
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
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  • I. Kiso
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
    Search for articles by this author
  • P. Freed
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
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  • C. Baechler
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
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  • M. Barnhart
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
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  • J. Riddle
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
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  • E. Mammen
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
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  • G. Mandell
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
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  • A. Kantrowitz
    Correspondence
    Reprint requests: Adrian Kantrowitz, M.D., Cardiovascular-Thoracic Surgery, Sinai Hospital of Detroit, 6767 W. Outer Dr., Detroil, Mich. 48235.
    Affiliations
    From the Department of Cardiovascular and Thoracic Surgery, Sinai Hospital of Detroit, Detroit, Mich., USA

    From the Department of Physiology, the College of Pharmacy and Allied Health Professions, Detroit, Mich., USA

    From the Department of Pathology, Wayne State University School of Medicine, Detroit, Mich., USA
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:0039606076902889
Permanent in-series cardiac assistance with the dynamic aortic patch: Blood-prosthesis interaction in long-term canine experiments
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      Abstract

      The blood-prosthesis interaction of the dynamic aortic patch (DAP), an in-series assist device for permanent circulatory support which is implanted in the descending thoracic aorta, was studied in 65 long-term experiments. Periods of postoperative observation with the device inactive or activated ranged from 2 weeks to 22 months. The intravascular surface of the DAP, fabricated of Dacron velour backed by bioelectric polyurethane, displayed various degrees of organization, ranging from a thin fibrin layer to a well organized pseudointima. Activation of the system did not prevent the development of an organized pseudointima. Changes in free-plasma hemoglobin were minimal; platelet count per square millimeter and state of reactivity remained within normal limits. Evidence of renal embolization, attributable to activation of the device, was found in five animals. Frequent lethal complications were aortic rupture and infections of the thoracic cavity originating at the implantation site. Further improvement of the DAP and the techniques of implantation is indicated to insure its efficacy during long-term implantation and activation.
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      Article info

      Publication history

      Accepted: August 25, 1975

      Footnotes

      ☆Supported by Grant HL-13737 from the National Heart and Lung Institute, National Institutes of Health.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606076902889

      Copyright

      © 1976 Published by Elsevier Inc.

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