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Abstract
Amikacin has been used to treat Providencia stuartii infections on the Burn Service at Los Angeles County/University of Southern California
Medical Center since March 1973. The median minimal inhibitory concentration (MIC)
of strains collected on this service prior to the introduction of amikacin was 3.13
μg. per milliliter, whereas the median MIC of strains collected during the last 4
months of the study was 12.5 μg per milliliter. High bactericidal concentrations (MBC)
noted at the time of initial studies predicted the emergence of resistant clones,
with MBC values rising to as great as 100 μ per milliliter. Further, isolates from
burn patients during the initial 5 days of treatment with amikacin had a median MIC
of 6.25 μg per milliliter, in contrast to values of 25 μg per milliliter in strains
isolated after 5 days of treatment. The epidemiologic significance of intensive treatment
of gram-negative infections occurring in a closed population with selected antibiotics
is discussed. The performance of susceptibility tests which included determination
of bactericidal concentrations was a major tool in the recognition of the potential
for selection of resistant micro-organisms.
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References
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Article info
Publication history
Accepted:
August 29,
1975
Footnotes
☆Supported in part by a Grant-in-Aid from Bristol Laboratories, Syracuse, N. Y., and the Hastings Infectious Disease Foundation, Los Angeles, Calif.
☆☆Presented in part at the Fourteenth International Conference on Antimicrobial Agents and Chemotherapy, San Francisco, Calif., Sept. 11–13 1974.
Identification
Copyright
© 1976 Published by Elsevier Inc.
