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Abstract
In this study the role that contraction plays in the healing of gastric wounds is
explored experimentally. Superficial gastric mucosal defects made in the columnar
part of rat stomachs were found to close rapidly, compared to defects carried down
into the muscle layer. The collagen was packed tightly at the edges of the defects
and no other factors appeared to have played a part in the closure. It is surmised
that the decrease in size of the defect is due to fibroblastic activity causing contraction.
It would seem likely that the myofibroblast, as described by other investigators,
would be the unique cell causing this action. Further studies are required to confirm
or refute this hypothesis.
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References
- Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction.Experimentia. 1971; 27: 549
- Granulation tissue as a contractile organ: A study of structure and function.J. Exp. Med. 1972; 135: 719
- On “The contractile fibroblast”.Plast. Reconstr. Surg. 1973; 52: 291
- Contraction of experimental wounds. Inhibiting wound contraction by using a topical smooth muscle antagonist.Surgery. 1974; 76: 8
- Wound contraction.Surg. Gynecol. Obstet. 1967; 125: 131
Article info
Publication history
Accepted:
November 3,
1975
Identification
Copyright
© 1976 Published by Elsevier Inc.
