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After administration of high systemic doses of heparin verified by assay, common carotid arteries in the rat were divided and sutured. Scanning electron microscope observations of endothelial surfaces showed a decrease in platelet adhesion, as well as a reduction in the adherence of other circulatory blood elements when compared to controls. This is the first report indicating the in vivo effect of high dose systemic heparin on platelets.
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- Scanning electron microscopic observations of the common carotid artery endothelium in the rat. II. Sutured arteries.Surg. Neurol. 1975; 4: 258
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Accepted: November 3, 1975
© 1976 Published by Elsevier Inc.