Brief clinical report| Volume 79, ISSUE 5, P597-600, May 1976

Vascular insufficiency secondary to ergotism

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      A case of ergot-induced peripheral vascular insufficiency mimicking atherosclerosis is presented and the clinical symptoms with vascular laboratory evaluation and roentgenographic findings are discussed in detail. A review of the literature of the vascular complications of ergot alkaloids is presented. After considering the various therapeutic modalities employed, a conservative, but hopefully more rational, treatment for these lesions is recommended. Although uncommon, this problem always must be considered in the differential diagnosis of the young patient, especially female, who presents with visceral or peripheral arterial insufficiency.
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        • Bagby R.
        • Cooper R.D.
        Angiography in ergotism. Report of two cases and review of the literature.
        Am. J. Roentgenol. Radium Ther. Nucl. Med. 1972; 116: 179
        • Bollinger A.
        • Preter B.
        Spasm of limb arteries due to ergotamine tartrate.
        Dtsch. Med. Wschr. 1973; 98: 825
        • Buenger R.
        • Hunter J.
        Reversible mesenteric artery stenoses due to methysergide maleate.
        J. A. M. A. 1966; 198: 144
        • Fedotin M.
        • Hartman C.
        Ergotamine poisoning producing renal arterial spasm.
        N. Engl. J. Med. 1970; 283: 518
        • Goldfischer J.
        Acute myocardial infarction secondary to ergot therapy.
        N. Engl. J. Med. 1960; 262: 860
        • Goodman L.
        • Gilman A.
        The pharmacological basis of therapeutics.
        in: ed. 3. A textbook of pharmacology, toxicology and therapeutics for physicians and medical students. Macmillan Publishing Co., Inc.,, New York1970: 897-907
        • Haynes C.D.
        • Davis M.E.
        Ergotism: Report of a case with localized arteriographic changes in the femoral vessel.
        Angiology. 1968; 19: 199
        • Herlache J.
        • Hoskins P.
        • Schmidt C.
        Ergotism: Unilateral brachial artery thrombosis secondary to ergotamine tartrate.
        Angiology. 1973; 24: 369
        • Imui C.
        Arterial spasm associated with oral ergotamine therapy.
        Br. J. Clin. Prac. 1973; 27: 457
        • Iuel J.
        • Mune O.
        Peripheral arterial insufficiency in ergotism.
        Vasc. Dis. 1967; 4: 159
        • Kravitz D.
        Neuroretinitis associated with symptoms of ergot poisoning.
        Arch. Ophthalmol. 1935; 13: 201
        • London M.
        • et al.
        Acute ergot poisoning.
        Angiology. 1970; 21: 565
        • Merhoff G.C.
        • Porter J.M.
        Ergot intoxication: Historical review and description of unusual clinical manifestations.
        Ann. Surg. 1974; 180: 773
        • McLoughlin M.
        • Sanders R.
        Ergotism causing peripheral vascular ischemia.
        Rocky Mt. Med. J. 1972; 69: 45
        • Pader E.
        Leriche syndrome in a patient with prolonged and continuous use of ergot derivative.
        Vasc. Dis. 1967; 4: 380
        • Prohult J.
        • Forsber O.
        • Hellstron R.
        Case of multiple arterial thromboses after oral contraceptives and ergotamine.
        Acta Med. Scand. 1967; 181: 453
        • Rizk F.
        • El-Khoury G.
        • Deeb Z.
        Peripheral arterial ischemia due to ergotism.
        J. Cardiovasc. Surg. (Torino). 1973; 14: 353
        • Storch T.
        Complications following the use of ergotamine tartrate.
        J. A. M. A. 1938; 111: 293
        • Sutton D.
        • Preston B.
        Angiography in peripheral ischemia due to ergotism.
        Br. J. Radiol. 1970; 43: 776
        • Yater W.
        • Cahill J.
        Bilateral gangrene of feet due to ergotamine tartrate used for pruritus of jaundice.
        J. A. M. A. 1936; 106: 1926